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姓　　名： 伍一军
学　　科： 细胞生物学
电话/传真： +86-10-64807251 / +86-10-64807099
电子邮件： wuyj@ioz.ac.cn
通讯地址： 北京市朝阳区北辰西路1号院5号
中国科学院动物研究所 农业虫害鼠害综合治理研究国家重点实验室 100101
更多信息： 分子毒理学研究组     

简历介绍：

　　伍一军现任中国科学院动物研究所研究员，博士研究生导师，主持分子毒理学实验室，担任研究组组长。中国科学院研究生院/动物研究所获得理学博士学位后赴美国Medical College of Georgia分子医学与遗传学系完成博士后研究（基因调控方向）。先后赴University of Louisiana（1999-2000年）、Oregon Health & Science University（2007-2008年）、Duke University（2010-2011年）、Virginia Commonwealth University（2015-2016年）等高校作为高级研究学者从事学术访问与合作研究。兼任中国科学院研究生院教授、中国科学技术大学博士生导师、中国科学院动物研究所学位委员会委员、国家自然科学基金项目评审专家、教育部学位中心论文评审专家、中国毒理学会生化与分子毒理学专业委员会常务委员、中国毒理学会神经毒理学专业委员会副主任委员、中国环境诱变剂学会环境诱变剂及神经毒理专业委员会常务委员、国家食品药品监督管理局化妆品安全专家委员会委员、北京市预防医学会卫生毒理学专业委员会常务委员、中华医学会《中华劳动卫生职业病杂志》编委、《Scientific Reports》编委、《Insect Science》与《昆虫学报》编委、《实验动物学报》编委、《中国比较医学杂志》通讯编委、《农药学学报》编委。

　　专业方向为分子毒理学/分子医学，主要研究领域为神经毒理学、环境毒理学以及药物引起的神经疾病。主要研究兴趣是环境化学物的神经毒性机制；低剂量化学物的慢性毒性机理；化学物的联合多毒性作用及其机制、有机磷引起的迟发性神经毒性的分子机制；神经病靶酯酶的功能与调节等。

　　先后主持承担国家自然科学基金项目、中科院生物特别支持项目、国际合作项目、国家863计划项目、国家973计划项目（子课题），中国科学院知识创新工程重大项目（专题）、国家科技支撑计划重大项目、中国科学院先导项目（子课题）等多项课题。近年来，带领分子毒理学实验室团队运用现代生物学技术研究化学物的毒性效应机制以及食品安全中的污染物毒性问题，取得重要进展。使用的模型包括细胞系、原代培养细胞、动物模型等，使用的技术手段和方法包括组学技术、细胞学技术、基因编辑技术、蛋白质相互作用技术、基因编辑技术等。已在国际重要核心学术期刊（SCI源刊）上发表研究论文近100篇。

　　已培养毕业博士生和硕士生27人，多人获国家奖学金和中科院奖学金，毕业后赴美留学工作和从事博士后研究。国内就业单位中已有4位博士毕业生晋升为教授/研究员和博士生导师、8人晋升为副教授/副研究员和研究生导师。现有在读博士生5人，硕士生3人。

研究领域：

社会任职：

获奖及荣誉：

承担科研项目情况：

　　目前在研任务主要是承担国家973计划项目、国家自然科学基金项目以及中国科学院战略性先导专项等科研项目。

代表论著：

  1. Xu HY, Sun YJ, Sun YY, Wu YJ, Xu MY, Chen LP, Zhu L. Lapatinib alleviates TOCP-induced axonal damage in the spinal cord of mouse. Neuropharmacology. 2021, 189: 108535.
  2. Li J, Qin Q, Li YX, Leng XF, Wu YJ. Tri-ortho-cresyl phosphate exposure leads to low egg production and poor eggshell quality via disrupting follicular development and shell gland function in laying hens. Ecotoxicol Environ Saf. 2021, 225: 112771.
  3. Chen LP, Xing XJ, Kang KL, Yang WY, Luo L, Wu YJ. Why are Drosophila larvae more sensitive to avermectin than adults? Comp Biochem Physiol Part C. 2022, 251: 109197.
  4. Wang P, Wu YJ, Sun ML. Decrease of an intracellular organic osmolyte contributes to the cytotoxicity of organophosphate in neuroblastoma cells in vitro. Toxicology. 2021, 453:152725.
  5. Li Q, Li J, Kang KL, Wu YJ. A safety type of genetically engineered bacterium that degrades chemical pesticides. AMB Express. 2020, 10(1): e33.
  6. Xu MY, Sun YJ, Wang P, Yang L, Wu YJ. Metabolomic biomarkers in urine of rats following long-term low-dose exposure of cadmium and/or chlorpyrifos. Ecotoxicol Environ Saf. 2020, 195: 110467.
  7. Xu MY, Wang P, Sun YJ, Yang L, Wu YJ. Identification of metabolite biomarkers in serum of rats exposed to chlorpyrifos and cadmium. Sci Rep. 2020, 10(1): e4999.
  8. Hou RY, Wang L, Wu YJ. Predicting ATP-binding cassette transporters using the random forest method. Front Genet. 2020, 11: 156.
  9. Hou RY, Wu J, Xu L, Zou Q, Wu YJ. Computational prediction of protein arginine methylation based on composition-transition-distribution (CTD) features. ACS Omega. 2020, 5(42):27470-27479.
  10. Wang P, Yang M, Jiang L, Wu YJ. A fungicide miconazole ameliorates tri-o-cresyl phosphate-induced demyelination through inhibition of ErbB/Akt pathway. Neuropharmacolgy. 2019, 148: 31-39.
  11. Xu MY, Wang P, Sun YJ, Wu YJ. Disruption of kidney metabolism in rats after subchronic combined exposure to low-dose cadmium and chlorpyrifos. Chem Res Toxicol. 2019, 32 (1):122–129.
  12. Jiang L, Wang P, Sun YJ, Wu YJ. Ivermectin reverses the drug resistance in cancer cells through EGFR/ERK/Akt/NF-κB pathway. J Exp Clin Cancer Res. 2019, 38:265.
  13. Liang YJ, Wang P, Wang HP, Long DX, Sun YJ, Wu YJ. Time-course changes in urine metabolic profiles of rats following 90-day exposure to propoxur. Sci Rep. 2019, 9(1): e16989.
  14. Xu HY, Wang P, Sun YJ, Xu MY, Zhu L, Wu YJ. Activation of neuregulin 1/ErbB signaling is involved in the development of TOCP-induced delayed neuropathy. Front Mol Neurosci. 2018, 11:129.
  15. Xu HY，Wang P, Sun YJ, Jiang L, Xu MY, Wu YJ. Autophagy in tri-o-cresyl phosphate-induced delayed neurotoxicity. J Neuropathol Exp Neurol. 2017, 76 (1): 52-60.
  16. Xu MY, Wang P, Sun YJ, Yang L, Wu YJ. Joint toxicity of chlorpyrifos and cadmium on the oxidative stress and mitochondrial damage in neuronal cells. Food Chem Toxicol. 2017, 103: 246-252.
  17. Wang P, Wang J, Sun YJ, Yang L, Wu YJ. Cadmium and chlorpyrifos inhibit cellular immune response in spleen of rats. Environ Toxicol. 2017, 32: 1927-1936.
  18. Xu MY, Wang P, Sun YJ, Wu YJ. Metabolomic analysis for combined hepatotoxicity of chlorpyrifos and cadmium in rats. Toxicology. 2017, 384: 50-58.
  19. Wang P, Xu MY, Liang YJ, Wang HP, Sun YJ, Long DX, Wu YJ. Subchronic toxicity of low dose propoxur, permethrin, and their combination on the redox status of rat liver. Chem-Biol Interact. 2017, 272: 21-27.
  20. Long DX, Wang P, Sun YJ, Chen R, Wu YJ. Neuropathy target esterase is degraded by the ubiquitin-proteasome pathway with ARA54 as the ubiquitin ligase. Biochemistry. 2015, 54(50):7385-7392.
  21. Wang P, Wang Q, Yang L, Qin QL, Wu YJ. Characterization of lysophosphatidylcholine-induced changes of intracellular calcium in Drosophila S2 cells. Life Sci. 2015, 131: 57-62.
  22. Xu MY, Sun YJ, Wang P, Xu HY, Chen LP, Zhu L, Wu YJ. Metabolomics analysis and biomarker identification for brains of rats exposed subchronically to the mixtures of low-dose cadmium and chlorpyrifos. Chem Res Toxicol. 2015, 28 (6):1216-1223.
  23. Wang P, Wu YJ. Applications of metabonomics to pesticide toxicology. Curr Drug Metab. 2015, 16(3): 191-199.
  24. Wang P, Wang HP, Xu MY, Liang YJ, Sun YJ, Yang L, Li L, Li W, Wu YJ. Combined subchronic toxicity of dichlorvos with malathion or pirimicarb in mice liver and serum: a metabonomic study. Food Chem Toxicol 2014, 70:222-230.
  25. Luo L, Sun YJ, Yang L, Huang S, Wu YJ. Abamectin induces P-glycoprotein expression in S2 cells via calcium/calmodulin/NF-κB pathway. Chem-Biol Interact. 2013, 203:430-439.
  26. Chen JX, Sun YJ, Wang P, Long DX, Li W, Li L, Wu YJ. Induction of autophagy by TOCP in differentiated human neuroblastoma cells lead to degradation of cytoskeletal components and inhibition of neurite outgrowth. Toxicology. 2013, 310:92-97.
  27. Luo L, Sun YJ, Wu YJ. Abamectin resistance in Drosophila is related to increased expression of P-glycoprotein via the dEGFR and dAkt pathways. Insect Biochem Mol Biol. 2013, 43:627-634.
  28. Zhu L, Wang P, Qin QL, Zhang H, Wu YJ. Protective effect of polypeptide from larva of housefly (Musca domestica) on hydrogen peroxide-induced oxidative damage in HepG2 cells. Food Chem Toxicol. 2013, 60:385-390.
  29. Sun YJ, Wang HP, Liang YJ, Yang L, Li W, Wu YJ. An NMR-based metabonomic investigation of the subacute effects of melamine in rats. J Proteome Res. 2012, 11: 2544-2550.
  30. Liang YJ, Wang HP, Long DX, Wu YJ. Applying biofluid metabonomic techniques to analyze the combined subchronic toxicity of propoxur and permethrin in rats. Bioanalysis. 2012, 4(24):2897-2907
  31. Wang Q, Wu YJ. Lysophosphatidylcholine induces Ca2+ mobilization in Jurkat human T lymphocytes and CTLL-2 mouse T lymphocytes by different pathways. Eur J Pharm Sci. 2011, 44: 602-609.
  32. Chen JX, Long DX, Hou WY, Li W, Wu YJ. Regulation of neuropathy target esterase by the cAMP/protein kinase A signal. Pharmacol Res. 2010,62: 259-264.
  33. Chang PA, Wu YJ. Neuropathy target esterase: An essential enzyme for neural development and axonal maintenance, Int J Biocehm Cell Biol. 2010, 42:573-575.
  34. Long DX, Chang PA, Liang YJ, Yang L, Wu YJ. Degradation of neuropathy target esterase by macroautophagic lysosomal pathway. Life Sci. 2009, 84:89-96.
  35. Li Q, Wu YJ. A fluorescent, genetically engineered micro-organism that degrades organophosphates and commits suicide when required. Appl Microbiol Biotechnol. 2009, 82:749-756.
  36. Liu CY, Chang PA, Wu YJ. Trichlorfon induces apoptosis in SH-SY5Y neuroblastoma cells via the endoplasmic reticulum? Chem-Biol Interact. 2009, 181:37-44.
  37. Hou WY, Long DX, Wu YJ. The homeostasis of phosphatidylcholine and lysophosphatidylcholine in nervous tissues of mice was not disrupted after administration of tri-o-cresyl phosphate. Toxicol Sci. 2009, 109:276-285.
  38. Long DX, Wu YJ. Growth inhibition and induction of G1 phase cell cycle arrest in neuroblastoma SH-SY5Y cell by tri-ortho-cresyl phosphate. Toxicol Lett. 2008, 181:47-52.
  39. Hou WY, Long DX, Wang HP, Wang Q, Wu YJ. The homeostasis of phosphatidylcholine and lysophosphatidylcholine was not disrupted during tri-o-cresyl phosphate induced delayed neurotoxicity in hens. Toxicology. 2008, 252:56-63.
  40. Li XH, Wu YJ. Characteristics of lysophosphatidylcholine-induced Ca2+ response in human neuroblastoma SH-SY5Y cells. Life Sci. 2007, 80:886-892.
  41. Chen R, Chang PA, Liu CY, Yang L, Wu YJ. G protein β2 subunit interacts directly with neuropathy target esterase and regulates its activity. Int J Biochem Cell Biol. 2007, 39:124-132.
  42. Wu YJ, Li M, Li YX, Li W, Dai JY, Leng XF. Verapamil abolished the enhancement of protein phosphorylation of brainstem mitochondria and synaptosomes from the hens dosed with tri-o-cresyl phosphate. Environ Toxicol Pharmacol. 2007, 24:67-71.
  43. Li XH, Long DX, Li W, Wu YJ. Different mechanisms of lysophosphotidylcholine-induced Ca2+ mobilization in N2a mouse and SH-SY5Y human neuroblastoma cells. Neurosci Lett. 2007, 424:22-26.
  44. Chang PA, Wu YJ, Li W, Leng XF. Effect of carbamate esters on neurite outgrowth in differentiating human SK-N-SH neuroblastoma cells. Chem-Biol Interact. 2006, 159: 65-72.
  45. Chang PA, Chen R, Wu YJ. Over-expression of neuropathy target esterase inhibits mammalian cell proliferation. Cell Proliferat. 2006, 39: 429-440.

写给考生的话：

　　分子毒理学实验室欢迎爱好生命科学研究的有志青年加入，欢迎医科和药科学生以及综合性大学和农科院校相关专业学生报考本研究方向的研究生。