姓  名: 周旭明
学  科: 基因组学、动物学
电话/传真: +86-10-64802412 / 
电子邮件: zhouxuming@ioz.ac.cn
通讯地址: 北京市朝阳区北辰西路1号院5号, 中国科学院动物研究所 中国科学院生态与保护生物学重点实验室 100101
更多信息: 动物适应与功能基因组学研究组     

简历介绍:

  周旭明,男,博士,研究员,博士生导师。中国科学院动物所动物生态与保护生物学院重点实验室研究员,动物适应与功能基因组学研究组组长。中国科学技术大学兼职博士生导师,北京市自然基金杰出青年基金获得者,《生物学杂志》编委。2014年博士毕业于中国科学院动物研究所,2014年至2018年在哈佛医学院从事博士后研究,2018年9月至今任中国科学院动物研究所研究员(PI)。现为中国动物学会兽类分会理事、国际分子生物与进化生物学学会和美国衰老协会会员。曾获得首届青岛-华大海洋新锐奖(2018)、湖南省自然科学奖二等奖(2018)、中国科学院优秀博士学位论文(2015)、国际哺乳动物学大会 travel award(2013)、江苏省优秀硕士学位论文(2012)等奖项和荣誉称号。实验室主要以哺乳动物为研究对象,从事系统学、适应性进化以及衰老机制等研究。目前已在Nature GeneticsNature communicationsMolecular Biology and EvolutionSystematic BiologyCell Reports等期刊发表 SCI 论文 30余篇。同时也是eLifeProceedings of the Royal Society BAging cellGenomics, proteomics & Bioinformatic等国际学术刊物审稿人。更多研究内容和团队成员信息欢迎访问实验室主页http://zhouxmlab.com/

研究领域:

  1、动物系统演化与辐射:即重建脊椎动物主要谱系的系统关系,揭示物种演化历程、形成以及濒危机制。例如我们曾利用系统发育基因组学的策略分析重建了北方兽类的系统发育关系,发现真盲缺目独立地位于劳亚兽的基部;支持鲸偶蹄目的单系发生;支持奇蹄目和鲸偶蹄目的姐妹群关系,以及食肉目与鳞甲目的姐妹群关系,恢复了猛真有蹄类的有效性。

  2、动物适应与寿命控制:以长寿动物为研究对象,系统解析衰老与适应的内在关联。例如通过裸鼹鼠等长寿啮齿类的功能基因组学研究揭示兽类适应性进化与抗衰老的分子机制。进化分析结合功能实验证实氧化还原过程和DNA修复等相关通路在长寿动物中受到选择作用,提升细胞耐受性和内环境稳定性。

  3、疫源动物生物学:即全面刻画疫源动物的生物学背景,为从源头上切断或降低疫情爆发风险提供基础研究支持。例如通过分析蝙蝠等疫源动物的基因组和行为数据特征,利用野外观察和转录组学的工具和方法,揭示蝙蝠等动物的遗传或者社会行为中关键因子,研究其生物学特性及携带致病微生物的跨种传播机制等。

社会任职:

  中国动物学会兽类分会理事

  国际分子生物与进化生物学学会会员

  美国衰老协会会员

  《生物学杂志》编委

获奖及荣誉:

  首届青岛-华大海洋新锐奖(2018)

  湖南省自然科学奖二等奖(2018)

  中国科学院优秀博士学位论文(2015年)

  江苏省优秀硕士学位论文(2013年)

承担科研项目情况:

  国家自然科学基金原创探索项目、北京市自然科学基金杰出青年项目、以及中科院先导专项等。

代表论著:

  1. Zhou X, Dou Q, Fan G, Zhang Q, Sanderford M, Kaya A, Johnson J, Karlsson E, Tian X, Mikhalchenko A, Kumar S, Seluanov A, Zhang Z, Gorbunova V, Liu X, Gladyshev V*. Beaver and Naked Mole Rat Genomes Reveal Common Paths to Longevity. Cell Rep. 2020. 32:107949.
  2. Zhou X*. Thoughts on Convergence Science of high-risk animals responsible for zoonotic epidemics. Scichina. 2020. Jul doi: 10.1360/TB-2020-0372.
  3. Wang P, Burley JT, Liu Y, Chang J, Chen D, Lu Q, Li SH, Zhou X, Edwards S*, Zhang Z*. Genomic Consequences of Long-term Population Decline in Brown Eared Pheasant. Mol Biol Evol. 2020. Aug 27:msaa213.
  4. Zhang H#, Liang Q#, Wang N, Wang Q, Leng L, Mao J, Wang Y, Wang S, Zhang J, Liang H, Zhou X, Li Y, Cao Z, Luan P, Wang Z, Yuan H, Wang Z, Zhou X, Lamont SJ, Da Y, Li R, Tian S*, Du Z*, Li H*. Microevolutionary Dynamics of Chicken Genomes under Divergent Selection for Adiposity. iScience. 2020 Jun 26;23(6):101193.
  5. Kaya A#, Mariotti M#, Tyshkovskiy A, Zhou X, Hulke ML, Ma S, Gerashchenko MV, Koren A, Gladyshev VN*. Molecular signatures of aneuploidy-driven adaptive evolution. Nat Commun. 2020 Jan 30;11(1):588.
  6. Sun D, Zhou X, Yu Z, Xu S, Seim I*, Yang G*. Accelerated evolution and diversifying selection drove the adaptation of cetacean bone microstructure. BMC Evol Biol. 2019 Oct 24;19(1):194.
  7. Li D#, Li Y#, Li M#, Che T, Tian S, Chen B, Zhou X, Zhang G, Gaur U, Luo M, Tian K, He M, He S, Xu Z, Jin L, Tang Q, Dai Y, Xu H, Hu Y, Zhao X, Yin H, Wang Y, Zhou R, Yang C, Du H, Jiang X, Zhu Q*, Li M*. Population genomics identifies patterns of genetic diversity and selection in chicken. BMC Genomics. 2019 Apr 2;20(1):263.
  8. Zhou X#, Guang X#, Sun D#, Xu S#, Li M, Seim I, Jie W, Yang L, Zhu Q, Xu J, Gao Q, Kaya A, Dou Q, Chen B, Ren W, Li S, Zhou K, Gladyshev VN, Nielsen R*, Fang X*, Yang G*. Population genomics of finless porpoises reveal an incipient cetacean species adapted to freshwater. Nat Commun. 2018 Apr 10;9(1):1276.
  9. Liu Z#, Tan X#, Orozco-terWengel P#, Zhou X, Zhang L, Tian S, Yan Z, Xu H, Ren B, Zhang P, Xiang Z, Sun B, Roos C, Bruford MW*, Li M*. Population genomics of wild Chinese rhesus macaques reveals a dynamic demographic history and local adaptation, with implications for biomedical research. Gigascience. 2018 Sep 1;7(9):giy106.
  10. Zhou X#, Sun D#, Guang X#, Ma S, Fang X, Mariotti M, Nielsen R, Gladyshev VN*, Yang G*. Molecular Footprints of Aquatic Adaptation Including Bone Mass Changes in Cetaceans. Genome Biol Evol. 2018 Mar 1;10(3):967-975.
  11. Li B*, Li M, Li J, Fan P, Ni Q, Lu J, Zhou X, Long L, Jiang Z, Zhang P, Huang Z, Huang C, Jiang X, Pan R*, Gouveia S, Dobrovolski R, Grueter C, Oxnard C, Groves C, Estrada A, Garber A*. The primate extinction crisis in China: immediate challenges and a way forward. Biodiversity and conservation. 2018 27: 3301-3327.
  12. Tang Q#, Gu Y#*, Zhou X#, Jin L, Guan J, Liu R, Li J, Long K, Tian S, Che T, Hu S, Liang Y, Yang X, Tao X, Zhong Z, Wang G, Chen X, Li D, Ma J, Wang X, Mai M, Jiang A, Luo X, Lv X, Gladyshev VN, Li X, Li M*. Comparative transcriptomics of 5 high-altitude vertebrates and their low-altitude relatives. Gigascience. 2017 Dec 1;6(12):1-9.
  13. Li D#, Che T#, Chen B#, Tian S#, Zhou X#, Zhang G#, Li M, Gaur U, Li Y, Luo M,Zhang L, Xu Z, Zhao X, Yin H, Wang Y, Jin L, Tang Q, Xu H, Yang M, Zhou R, Li R, Zhu Q*, Li M*. Genomic data for 78 chickens from 14 populations. Gigascience. 2017 Jun 1;6(6):1-5.
  14. Li M#*, Chen L#, Tian S#, Lin Y#, Tang Q#, Zhou X#, Li D, Yeung CKL, Che T, Jin L, Fu Y, Ma J, Wang X, Jiang A, Lan J, Pan Q, Liu Y, Luo Z, Guo Z, Liu H, Zhu L, Shuai S, Tang G, Zhao J, Jiang Y, Bai L, Zhang S, Mai M, Li C, Wang D, Gu Y, Wang G, Lu H, Li Y, Zhu H, Li Z, Li M, Gladyshev VN, Jiang Z, Zhao S, Wang J, Li R*, Li X*. Comprehensive variation discovery and recovery of missing sequence in the pig genome using multiple de novo assemblies. Genome Res. 2017 May;27(5):865-874.
  15. Zhou X#*, Meng X#, Liu Z#, Chang J#, Wang B#, Li M#, Wengel PO, Tian S, Wen C, Wang Z, Garber PA, Pan H, Ye X, Xiang Z, Bruford MW, Edwards SV, Cao Y, Yu S, Gao L, Cao Z, Liu G, Ren B, Shi F, Peterfi Z, Li D, Li B, Jiang Z, Li J, Gladyshev VN, Li R*, Li M*. Population Genomics Reveals Low Genetic Diversity and Adaptation to Hypoxia in Snub-Nosed Monkeys. Mol Biol Evol. 2016 Oct;33(10):2670-81.
  16. Li R, Jiang G*, Ren Q, Wang Y, Zhou X, Zhou C, Qin D. MicroRNAs of the mesothorax in Qinlingacris elaeodes, an alpine grasshopper showing a wing polymorphism with unilateral wing form. Bull Entomol Res. 2016 Apr;106(2):225-32.
  17. Zhou X, Seim I, Gladyshev VN*. Convergent evolution of marine mammals is associated with distinct substitutions in common genes. Sci Rep. 2015 Nov 9;5:16550.
  18. Wang B, Zhou X, Shi F, Liu Z, Roos C, Garber PA, Li M, Pan H*. Full-length Numt analysis provides evidence for hybridization between the Asian colobine genera Trachypithecus and Semnopithecus. Am J Primatol. 2015 Aug;77(8):901-10.
  19. Zhou X, Sun F, Xu S, Yang G*, Li M*. The position of tree shrews in the mammalian tree: Comparing multi-gene analyses with phylogenomic results leaves monophyly of Euarchonta doubtful. Integr Zool. 2015 Mar;10(2):186-98.
  20. Zhou X#, Wang B#, Pan Q#, Zhang J, Kumar S, Sun X, Liu Z, Pan H, Lin Y, Liu G, Zhan W, Li M, Ren B, Ma X, Ruan H, Cheng C, Wang D, Shi F, Hui Y, Tao Y, Zhang C, Zhu P, Xiang Z, Jiang W, Chang J, Wang H, Cao Z, Jiang Z, Li B, Yang G, Roos C, Garber PA, Bruford MW, Li R*, Li M*. Whole-genome sequencing of the snub-nosed monkey provides insights into folivory and evolutionary history. Nat Genet. 2014 Dec;46(12):1303-10.
  21. Zhu K#, Zhou X#, Xu S, Sun D, Ren W, Zhou K, Yang G*. The loss of taste genes in cetaceans. BMC Evol Biol. 2014 Oct 12;14:218.
  22. Seim I, Ma S, Zhou X, Gerashchenko MV, Lee SG, Suydam R, George JC, Bickham JW, Gladyshev VN*. The transcriptome of the bowhead whale Balaena mysticetus reveals adaptations of the longest-lived mammal. Aging (Albany NY). 2014 Oct;6(10):879-99.
  23. Zhou X#, Sun F#, Xu S#, Fan G, Zhu K, Liu X, Chen Y, Shi C, Yang Y, Huang Z, Chen J, Hou H, Guo X, Chen W, Chen Y, Wang X, Lv T, Yang D, Zhou J, Huang B, Wang Z, Zhao W, Tian R, Xiong Z, Xu J, Liang X, Chen B, Liu W, Wang J, Pan S, Fang X, Li M, Wei F, Xu X, Zhou K, Wang J*, Yang G*. Baiji genomes reveal low genetic variability and new insights into secondary aquatic adaptations. Nat Commun. 2013;4:2708.
  24. Xu S, Yang Y, Zhou X, Xu J, Zhou K, Yang G*. Adaptive evolution of the osmoregulation-related genes in cetaceans during secondary aquatic adaptation. BMC Evol Biol. 2013 Sep 9;13:189.
  25. Ren Q, Fan Z, Zhou X, Jiang G*, Wang Y, Liu Y. Identification and characterization of anonymous nuclear markers for the double-striped cockroach, Blattella bisignata. Bull Entomol Res. 2013 Feb;103(1):29-35.
  26. Xu S, Chen Y, Cheng Y, Yang D, Zhou X, Xu J, Zhou K, Yang G*. Positive selection at the ASPM gene coincides with brain size enlargements in cetaceans. Proc Biol Sci. 2012 Nov 7;279(1746):4433-40.
  27. Wang L, Zhou X, Nie L*, Xia X, Liu L, Jiang Y, Huang Z, Jing W. The complete mitochondrial genome sequences of Chelodina rugosa and Chelus fimbriata (Pleurodira: Chelidae): implications of a common absence of initiation sites (O(L)) in pleurodiran turtles. Mol Biol Rep. 2012 Mar;39(3):2097-107.
  28. Zhou X, Xu S, Xu J, Chen B, Zhou K, Yang G*. Phylogenomic analysis resolves the interordinal relationships and rapid diversification of the laurasiatherian mammals. Syst Biol. 2012 Jan;61(1):150-64.
  29. Zhou X, Xu S, Yang Y, Zhou K, Yang G*. Phylogenomic analyses and improved resolution of Cetartiodactyla. Mol Phylogenet Evol. 2011 Nov;61(2):255-64.
  30. Luo C, Ai H, Zhou X, Min C, Liang Z, Zhang J, Song R, Liu M*, Zhang S*. Molecular structure, expression analysis and functional characterization of APRIL (TNFSF 13) in goat (Capra hircus). Gene. 2011 Oct 10;485(2):63-8.
  31. Ai H#, Zhang Z#, Shen Y, Zhang J, Zhou X, Min C, Zhu S, Zhang S*. Molecular structure, phylogenetic analysis, tissue distribution, and function characterization of interferon-γ-inducible lysosomal thiol reductase (GILT) gene in sheep (Ovis aries). Vet Immunol Immunopathol. 2011 Apr 15;140(3-4):329-34.
  32. Zhou X, Xu S, Zhang P, Yang G*. Developing a series of conservative anchor markers and their application to phylogenomics of Laurasiatherian mammals. Mol Ecol Resour. 2011 Jan;11(1):134-40.
  33. Xu S, Ren W, Zhou X, Zhou K, Yang G*. Sequence polymorphism and geographical variation at a positively selected MHC-DRB gene in the finless porpoise (Neophocaena phocaenoides): implication for recent differentiation of the Yangtze finless porpoise? J Mol Evol. 2010 Jul;71(1):6-22.

写给考生的话:

  自强不息,追求卓越