孟凡伟，男，博士，副研究员，硕士生导师，中国科学院动物研究所动物进化与系统学院重点实验室鱼类进化与基因组学研究组成员。2003年获得吉林大学生物学理学硕士学位；2008年于清华大学生物科学与技术系，获得发育生物学博士学位。同年进入中国科学院动物研究所进行博士后合作研究，2012年留所工作。长期从事鱼类适应性演化研究，研究结果发表在Mol Biol Evol、J Cell Sci、J Mol Evol、Curr Zool等学术杂志上。主持国家自然科学基金青年和面上项目三项、参与973、第三次新疆综合科学考察等项目。

　　洞穴生境具有终年无光、相对封闭、缺少植物的光合作用、食物匮乏等特征，生物在洞穴中生存需要依靠它们独特的适应能力和资源利用策略。我们利用进化发育生物学的实验手段，以斑马鱼和金线鲃为模式动物对洞穴鱼类多组织、器官适应洞穴环境的分子机制进行研究，揭示洞穴生物适应性演化机制、促进洞穴鱼类物种多样性的保护。

1. Lam SM, Li J, Sun H, Mao W, Lu Z, Zhao Q, Han C, Gong C, Jiang B, Chua GH, Zhao Z, Meng F*#, and Shui G*#. Quantitative Lipidomics and Spatial MS-Imaging Uncovered Neurological and Systemic Lipid Metabolic Pathways Underlying Troglomorphic Adaptations in Cave-Dwelling Fish. Mol Biol Evol 2022, 39(4): msac050.
2. Zhao Y, Huang Z, Huang J, Zhang C, Meng F*. 2020. Phylogenetic analysis and expression differences of eye-related genes in cavefish genus Sinocyclocheilus. Integr Zool 2021 May;16(3):354-367
3. Huang Z, Titus T, Postlethwait JH*, Meng F*. 2019. Eye Degeneration and Loss of otx5b Expression in the Cavefish Sinocyclocheilus tileihornes. J Mol Evol 87:199-208.
4. Meng F*, Zhao Y, Titus T, Zhang C, Postlethwait JH*. 2018. Brain of the blind: transcriptomics of the golden-line cavefish brain. Curr Zool 64:765-773.
5. Meng F, Braasch I, Phillips JB, Lin X, Titus T, Zhang C, Postlethwait JH. 2013. Evolution of the eye transcriptome under constant darkness in Sinocyclocheilus cavefish. Mol Biol Evol 30:1527-1543.
6. Meng F, Zhao Y, Postlethwait JH, Zhang C. 2013. Differentially-expressed opsin genes identified in Sinocyclocheilus cavefish endemic to China. Curr Zool 59:170-174.
7. Li F, Lan Y, Wang Y, Wang J, Yang G, Meng F, Han H, Meng A, Wang Y, Yang X. 2011. Endothelial Smad4 maintains cerebrovascular integrity by activating N-cadherin through cooperation with Notch. Dev Cell 20:291-302.
8. Meng F, Cheng X, Yang L, Hou N, Yang X, Meng A. 2008. Accelerated re-epithelialization in Dpr2-deficient mice is associated with enhanced response to TGFbeta signaling. J Cell Sci 121:2904-2912.
9. Meng F, Meng A. 2008. Dapper family members modulate distinct signaling pathways in vertebrate development. Trends in Developmental Biology 1(3):61-69
10. Meng F^#, Shi L^#, Cheng X, Hou N, Wang Y, Teng Y, Meng A, Yang X. 2007. Surfactant protein A promoter directs the expression of Cre recombinase in brain microvascular endothelial cells of transgenic mice. Matrix Biol 26:54-57.
11. Zhang C, Meng F, Wang C, Guo H, Fan M, Liu S, Zhou R, He F. 2004. Identification of a novel alternative splicing form of human netrin-4 and analyzing the expression patterns in adult rat brain. Brain Res Mol Brain Res 130:68-80.
12. Meng F, Guo H, Zhou R, Zhang C. 2004. Expression and distribution of β-Netrin mRNA in the brain of adult rat. Chinese Journal of Neuroscience, Vol.20 No.4, P286-289.

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