陈敏，女，博士，副研究员，干细胞与生殖生物学国家重点实验室性别决定与性别分化研究组成员。2007年毕业于中科院动物研究所，获理学博士学位，研究方向为性腺生物学。2011年到2014年在中科院动物所做博士后研究，2014年加入性别决定与性别分化研究组工作，2022年晋升为副研究员。

　　性腺体细胞和生殖细胞的分化调控

　　国家自然科学基金面上项目（32170855），2022-2025，主持

　　国家自然科学基金青年科学基金项目（31601193），2017-2019，主持

　　国家重点研发计划（2018YFC1004200），2018-2021，项目骨干

1. Chen M^#, Dong F^#, Chen M, Shen Z, Wu H, Cen C, Cui X, Bao S, Gao F. PRMT5 regulates ovarian follicle development by facilitating Wt1 translation. Elife. 2021 Aug 27;10:e68930. doi: 10.7554/eLife.68930.
2. Chen M^#, Long X^#, Chen M^#, Hao F, Kang J, Wang N, Wang Y, Wang M, Gao Y, Zhou M, et al. Integration of single-cell transcriptome and chromatin accessibility of early gonads development among goats, pigs, macaques, and humans. Cell Rep. 2022 Nov 1;41(5):111587. doi: 10.1016/j.celrep.2022.111587.
3. Dong F^#, Chen M^#, Chen M, Jiang L, Shen Z, Ma L, Han C, Guo X, Gao F. PRMT5 Is Involved in Spermatogonial Stem Cells Maintenance by Regulating Plzf Expression via Modulation of Lysine Histone Modifications. Front Cell Dev Biol. 2021 May 21;9:673258. doi: 10.3389/fcell.2021.673258.
4. Chen M^#, Chen M^#, Chen S, Zhou J, Dong F, Shen Z, Wu H, Cui X, Gao F. Abnormal Meiosis Initiation in Germ Cell Caused by Aberrant Differentiation of Gonad Somatic Cell, Oxid Med Cell Longev, 2019 Sep 5;2019:8030697. doi: 10.1155/2019/8030697.
5. Chen M^#, Zhang L^#, Cui X, Lin X, Li Y, Wang Y, Wang Y, Qin Y, Chen D, Han C, Zhou B, Huff V, Gao F. Wt1 directs the lineage specification of sertoli and granulosa cells by repressing Sf1 expression, Development, 2017 Jan 1,144(1):44-53. doi: 10.1242/dev.144105.
6. Zhang L^#, Chen M^#, Wen Q, Li Y, Wang Y, Wang Y, Qin Y, Cui X, Yang L, Huff V, Gao F. Reprogramming of Sertoli cells to fetal-like Leydig cells by Wt1 ablation, Proc Natl Acad Sci U S A., 2015 Mar 31,112(13):4003-8. doi: 10.1073/pnas.1422371112.
7. Chen M^#, Li S^#, Liu S^#, Zhang Y^#, Cui X, Lv L, Liu B, Zheng A, Wang Q, Duo S, Gao F. Infection of SARS-CoV-2 causes severe pathological changes in mouse testis. J Genet Genomics. 2023 Feb;50(2):99-107. doi: 10.1016/j.jgg.2022.11.011. Epub 2022 Dec 6.
8. Chen M, Cen C, Wang N, Shen Z, Wang M, Liu B, Li J, Cui X, Wang Y, Gao F. The functions of Wt1 in mouse gonad development and somatic cells differentiation. Biol Reprod. 2022 Jul 25;107(1):269-274. doi: 10.1093/biolre/ioac050.
9. Cen C^#, Chen M^#, Zhou J, Zhang L, Duo S, Jiang L, Hou X, Gao F. Inactivation of Wt1 causes pre-granulosa cell to steroidogenic cell transformation and defect of ovary development. Biol Reprod. 2020 Jun 23;103(1):60-69. doi: 10.1093/biolre/ioaa042.
10. Chen M, Wang X, Wang Y, Zhang L, Xu B, Lv L, Cui X, Li W, Gao F. Wt1 is involved in leydig cell steroid hormone biosynthesis by regulating paracrine factor expression in mice. Biol Reprod. 2014 Apr 3;90(4):71. doi: 10.1095/biolreprod.113.114702. Print 2014 Apr.
11. Liu W, Chen M, Liu C, Wang L, Wei H, Zhang R, Ren Z, Chen Y, Luo M, Zhao J, Jiang H, Gao F, Li W. Epg5 deficiency leads to primary ovarian insufficiency due to WT1 accumulation in mouse granulosa cells. Autophagy. doi.org/10.1080/15548627.2022.2094671.
12. Shen Z, Chen M, Gao Y, Dong F, Cen C, Wu H, Wang N, Cui X, Han C, Gao F. The function of Foxo1 in spermatogonia development is independent of PI3K/PTEN signaling. FASEB J. 2022 Oct;36(10):e22522. doi: 10.1096/fj.202200640RR.
13. 13 Chen SR, Chen M, Wang XN, Zhang J, Wen Q, Ji SY, Zheng QS, Gao F, Liu YX. The Wilms tumor gene, Wt1, maintains testicular cord integrity by regulating the expression of Col4a1 and Col4a2. Biol Reprod. 2013 Mar 7;88(3):56. doi: 10.1095/biolreprod.112.105379. Print 2013 Mar.
14. Chen M, Cai H, Yang JL, Lu CL, Liu T, Yang W, Guo J, Hu XQ, Fan CH, Hu ZY, Gao F, Liu YX. Effect of heat stress on expression of junction-associated molecules and upstream factors androgen receptor and Wilms' tumor 1 in monkey sertoli cells. Endocrinology. 2008 Oct;149(10):4871-82. doi: 10.1210/en.2007-1093. Epub 2008 Jun 5.
15. Chen M, Yuan JX, Shi YQ, Zhang XS, Hu ZY, Gao F, Liu YX. Effect of 43 degrees treatment on expression of heat shock proteins 105, 70 and 60 in cultured monkey Sertoli cells. Asian J Androl. 2008 May;10(3):474-85. doi: 10.1111/j.1745-7262.2008.00391.x.