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    WANG Xianhui
    +86-10-64807220  /  +86-10-64807099
    The State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing 100101, P.R.China
    Group of Behavioral Genetics      

    Postdoc experience, 2005-2007,  Department of Biology, University of Maryland, USA.
    Ph. D. in Molecular Ecology, 2001-2004, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
    Master in Insect Physiology, 1998-2001, Department of Plant Protection, Shandong Agricultural University, Taian, China.
    Bachelor in Biology, 1994-1998, Department of Plant Protection, Laiyang Agricultural College, Laiyang, China.
    Research Interest:
    My research is aimed at understanding behavioral plasticity involved in group-living by using ‘-omics’ technologies in two study models, locusts and bumblebees. I am carrying out following research works: (1) genomic and epigenomic mechanisms underlying phase change of the migratory locust, Locusta migratoria; (2) genomic mechanism underlying caste determination in bumblebees. (3) the whole genome sequencing for several locust and bumblebee species.
    Public Services:

    Awards and Honors:

    Research Grants:

    Selected Publication:
    1. Yang P.C., Hou, L., Wang X.H.*, Kang L.* 2019, Core transcriptional signatures of phase change in the migratory locust. Protein&Cell, DOI: 10.1007/s13238-019-0648-6 (*Co-corresponding author)
    2. Hou L., Li B.B., Ding D., Kang L.*, Wang X.H.* 2019, CREB-B acts as a key mediator of NPF/NO pathway involved in phase-related locomotor plasticity in locusts. PLoS Genetics, 15(5): e1008176. (*Co-corresponding author)
    3. Wei, J.N., Shao, W.B., Cao, M.M., Ge, J., Yang, P.C., Chen, L., Wang, X.H.*, Kang, L.* 2019, Phenylacetonitrile in locusts facilitates an antipredator defense by acting as an olfactory aposematic signal and cyanide precursor. Science Advances, DOI: 10.1126/sciadv.aav5495.  (*Co-corresponding author)
    4. Zhou, F., Kang, L.*, Wang, X.H.* 2019,JUMPING Detector: An automated monitoring equipment for the locomotion of jumping insects. Insect Science, DOI: 10.1111/1744-7917.12668. (*Co-corresponding author)
    5. Chen, D.F., Tang, J.X., Li, B.B., Hou, L., Wang, X.H.*, Kang, L.*, 2018, CRISPR/Cas9-mediated genome editing induces exon skipping by complete or stochastic altering splicing in the migratory locust. BMC Biotechnology, 18:60. (*Co-corresponding author)
    6. Guo, W., Ren, D.N., Zhao, L.F., Jiang, F., Song, J., Wang, X.H.*, Kang, L.*, 2018, Identification of Odorant-Binding Proteins (OBPs) and Functional Analysis of Phase-Related OBPs in the Migratory Locust. Frontiers in Physiology, doi: 10.3389/fphys.2018.00984. (*Co-corresponding author)
    7. Li, B.B., Hou, L., Zhu, D., Xu, X.L., An, S.H.*, Wang, X.H.*. 2018 Identification and caste-dependent expression patterns of DNA methylation associated genes in Bombus terrestris. Scientic Reports, 8: 2332. DOI:10.1038/s41598-018-20831-1 (*Co-corresponding author)
    8. Zhu, J., F. Jiang, X. Wang, P. Yang, Y. Bao, W. Zhao, W. Wang, H. Lu, Q. Wang, N. Cui, J. Li, X. Chen, L. Luo, J. Yu, L. Kang* and F. Cui* (2017). "Genome sequence of the small brown planthopper, Laodelphax striatellus." Gigascience 6(12): 1-12.
    9. Chen, Z.Z., Liu, L., Liu, S., Cheng, L., Wang, X.H., and Xu, Y*. 2017 Response of Chrysoperla nipponensis (Okamoto)(Neuroptera: Chrysopidae) Under Long and Short Photoperiods. Journal of insect science 17, 35.
    10. Jiang, F., Liu, Q., Liu, X., Wang, X.H.*, and Kang, L.* 2017 Genomic data from arthropods reveal high conservation but divergent evolutionary pattern of Polycomb/Trithorax group genes in arthropods. Insect science. doi: 10.1111/1744-7917.12558. (*Co-corresponding author)
    11. Jiang F, Liu Q, Wang Y.L., Zhang J., Wang H.M., Song T.Q., Yang M.L., Wang X.H. *, Kang L.* 2017 Comparative genomic analysis of SET-domain family reveals the origin, expansion, and putative function of the arthropod-specific SmydA genes as histone modifier in insects. GigaScience, gix031. (*Co-corresponding author)
    12. Hou, L., Yang, P.C., Jiang, F., Liu, Q., Wang, X.H. *, Kang, L. *  2017. The neuropeptide F/nitric oxide pathway is essential for shaping locomotor plasticity underlying locust phase transition. eLife 10.7554/eLife.22526. (*Co-corresponding author)
    13. Wei, J.N., Shao, W.B., Wang, X.H., Ge, J., Chen, X.Y., Yu, D., Kang L.* 2017. Composition and emission dynamics of migratory locust volatiles in response to changes in developmental stages and population density.Insect Science 24: 60-72.
    14. Li, Y., Zhang, J., Chen, D.F., Yang, P.C., Jiang, F., Wang, X.H.*, Kang, L.* 2016. CRISPR/Cas9 in locusts: Successful establishment of an olfactory deficiency line by targeting the mutagenesis of an odorant receptor co-receptor (Orco). Insect Biochemistry and Molecular Biology 79: 27-31. (*Co-corresponding author)
    15. Chen, B., Wang, X.H., Tu, Z.J., Huang, Y.P. 2016. Leap forward with insect genomics preface. Insect Science 23: 332-334.
    16. Li, J., Lu, Z.K., He, J., Chen, Q.Q., Wang, X.H., Kang, L., Li, X.D.* 2016. Alternative exon‐encoding regions of Locusta migratoria muscle myosin modulate the pH dependence of ATPase activity. Insect Molecular Biology doi: 10.1111/imb.12254
    17. Guo, S.Y., Jiang, F., Yang, P.C., Liu, Q., Wang X.H. *, Kang, L. * 2016. Characteristics and expression patterns of histone-modifying enzyme systems in the migratory locust. Insect Biochemistry and Molecular Biology 76: 18-28.  (*Co-corresponding author)
    18. Xu, J. J., Wan, G.J., Hu, D.B., He, J., Chen, F.J., Wang, X.H., Hua, H.X., Pan, W.D.* 2016. Molecular characterization, tissue and developmental expression profiles of cryptochrome genes in wing dimorphic brown planthoppers, Nilaparvata lugens. Insect science doi: 10.1111/1744-7917.12256.
    19. Wang, Z.F., Yang, P.C., Chen D.F., Jiang, F., Li, Y., Wang, X.H. *, Kang, L. *, 2015 Identification and functional analysis of olfactory receptor family reveal unusual characteristics of the olfactory system in the migratory locust. Cellular and Molecular Life Sciences, 72, 4429-4443. (*Co-corresponding author)
    20. Hou, L., Jiang, F., Yang, P.C., Wang, X.H.*, Kang, L.*, 2015 Molecular characterization and expression profiles of neuropeptide precursors in the migratory locust. Insect Biochemistry and Molecular Biology, 63, 63-71. (*Co-corresponding author)
    21. Wang, X.H., Fang, X.D., Yang, P.C., Jiang, X.T., Jiang, F., Zhao, D.J., Li, B.L., Cui, F., Wei, J.N., Ma, C., Wang, Y.D., He, J., Luo, Y., Wang, Z.F., Guo, X.J., Guo, W., Wang, X.S., Zhang, Y., Yang, M.L., Hao, S.G., Chen, B., Ma, Z.Y., Yu, D., Xiong, Z.Q., Zhu, Y.B., Fan, D.D., Han, L.J., Wang, B., Chen, Y.X., Wang, J.W., Yang, L., Zhao, W., Feng, Y., Chen, G.X., Lian, J.M., Li, Q.Y., Huang, Z.Y., Yao, X.M., Lv, N., Zhang, G.J., Li, Y.R., Wang, J., Wang, J., Zhu, B.L., Kang, L.*, 2014 Locust genome sequence provides insight into swarm formation and long-distance flight. Nature Communications 10.1038/ncomms3957.
    22. Wang, X.H., Kang, L., 2014. Molecular mechanisms of phase change in locusts. Annual Review of Entomology, 59, 225-243.
    23. Luo, Y., Wang, X.H.*, Yu, D., Chen, B., Kang, L., 2013. Differential responses of migratory locusts to systemic RNA interference via double-stranded RNA injection and feeding. Insect Molecular Biology, 22:574-583. (*The first co-author)
    24. Jiang, F., Yang, M.L., Guo, W., Wang, X.H., Kang, L., 2012, Large-scale transcriptome analysis of retroelements in the migratory locust, Locusta migratoria. PLoS One, 7: e40532.
    25. Wu, R., Wu, Z.M., Wang, X.H.*, Yang, P.C., Yu, D., Zhao, C.X., Xu, G.W. and Kang L., 2012. Metabolomic analysis reveals that carnitines are key regulatory metabolites in phase transition of the locusts. Proceedings of the National Academy of Sciences of (USA), 109: 3259-3263. (*The first co-author)
    26. Luo, Y., Wang, X.H.*, Yu, D., Kang, L., 2012. The SID-1 double-stranded RNA transporter is not required for systemic RNAi in the migratory locust. RNA Biology, 9:1-6. (*The first co-author)
    27. Wang, H.S., Ma, Z.Y., Cui, F. Wang, X.H., Guo, W., Yang, P.C. and Kang L., 2012. Parental phase status affects the cold hardiness of progeny eggs in locusts. Functional Ecology, 26:379–389.
    28. Guo, W., Wang, X.H.*, Ma, Z.Y., Xue, L., Han, J.Y., Yu, D., and Kang L., 2011. CSP and takeout genes modulate the switch between attraction and repulsion during behavioral phase change in the migratory locust. PLoS Genetics,7: e1001291, 1-13. (*The first co-author)
    29. Ma, Z.Y., Guo, W., Guo, X.J., Wang, X.H., Kang L., 2011, Modulation of behavioral phase changes of the migratory locust by the catecholamine metabolic pathway. Proceedings of National Academy of Sciences (USA),108: 3882-3887.
    30. Zhang, Y., Wang, X.H., and Kang L., 2011. A k-mer scheme to predict piRNAs and characterize locust piRNAs. Bioinformatics, 27: 771–776.
    31. Guo, W., Wang, X.H.*, Zhao, D.J., Yang, P.C. and Kang L., 2010. Molecular cloning and temporal-spatial expression of I element in gregarious and solitary locusts. Journal of Insect Physiology, 56: 943-948. (*The first co-author)
    32. Wang, X.H., Qi, X.L., and Kang L., 2010. Geographic differences on accumulation of sugars and polyols in locust eggs in response to cold acclimation. Journal of Insect Physiology, 56: 966-970.
    33. Baker, R.H., Morgan, J., Wang, X.H., Boore, J.L. and Wilkinson, G.S., 2009. Genomic analysis of a sexually-selected character: EST sequencing and microarray analysis of eye-antennal imaginal discs in the stalk-eyed fly Teleopsis dalmanni (Diopsidae). BMC Genomics, 10: 361.
    34. Wang, H.S., Wang, X.H.*, Guo, W., Zhang, S.F. and Kang L., 2007. cDNA cloning of heat shock proteins and their expression in the two phases of the migratory locust. Insect Molecular Biology, 16: 207-219. (*The first co-author)
    35. Qi, X.L., Wang, X.H*. and Kang L., 2007. Influence of soil moisture on egg cold hardiness in the migratory locust Locusta migratoria (Orthoptera:Acridiidae). Physiol. Entomol., 32: 219-224. (*The first co-author)
    36. Jing, X.H., Wang, X.H. and Kang L., 2005. Chill injury in the eggs of the migratory locust, Locusta migratoria (Orthoptera: Acrididae): the time-temperature relationship with high-temperature interruption. Insect Science, 12: 171-178.
    37. Wang, X.H., Kang L., 2005. Differences in egg thermotolerance between tropical and temperate populations of the migratory locust Locusta migratoria (Orthoptera: Acridiidae). Journal of Insect Physiology, 51: 1277-1285.
    38. Wang, X. H. and Kang L., 2003. Rapid cold hardening in young hoppers of the migratory locust Locusta migratoria L. (Orthoptera:Acridiidae). CryoLetters,24: 331-340.
    39. Wang, X.H., QI X.L., Kang L. 2003. Rapid cold hardening process of insects and its ecological adaptive significance.Prog. Nat. Sci. 13: 641-647.