Location: Home > Scientists
  Principal Investigators
HU Baoyang
Stem Cell Biology and Regenerative Medicine
+86-10-64806251  / 
Institute of Stem Cell and Regenerative, Chinese Academy of Siences, Yard A3, Datun Road, Chaoyang District, Beijing, 100101, P.R.China
Hu's Group      

Dr. Hu Baoyang is the Principal Investigator of Stem Cell Biology and Regenerative Medicine Lab at the Institute of Zoology, Chinese Academy of Sciences. He is currently the Executive Director of the Institute of Stem Cell and Regenerative, Chinese Academy of Science, the Executive Vice President of the Savaid Medical School of the University of Chinese Academy of Sciences and the deputy director of the State Key Laboratory of Stem Cell and Reproductive Biology.

Dr. Hu got his Ph. D degree in Fudan University in 2004. In 2005, Hu went to Dr. Su-Chun Zhang's stem cell research lab at the University of Wisconsin-Madison working on neural differentiation. He joined the Institute of Zoology at the Chinese Academy of Sciences in 2011.

Dr. Hu's lab focuses on brain development and disease, stem cell differentiation and clinical application, and has a series of important achievements in the evolutionary characteristics of brain development and regulation, the differentiation mechanism of the nervous system, and the clinical application of differentiated cells. Dr. Hu and his team discovered the heterogeneity and regularity of neural differentiated human iPS for the first time (PNAS, 2010), firstly acquired the SIRT6 knockout monkeys and revealed its regulatory and evolutionary properties (Nature, 2018), and took the head in promoting the Clinical studies of treating Parkinson's disease with hESC differentiation cell.

He has undertaken many scientific research projects of the Ministry of Science and Technology, the National Natural Science Foundation of Chinese, and the Chinese Academy of Sciences. He has published more than 40 prestigious papers in journals such as Nature, Science, Cell Stem Cells, PNAS, Cell Research, and won 2 US patents. He has served as a reviewer of various international academic journals and has been invited to participate in international and domestic academic exchanges. He is also the deputy head of the special expert group for stem cell and transformation research of the National Major Research and Development Program, the executive director of the Chinese Society of Cell Biology, and the director of the Stem Cell Branch.

Research Interests:
Our lab is investigating neural differentiation and stem cell translational.

Awards and Honors:

2020, Outstanding Science and Technology Achievement Prize of the CAS.

2019, Stem Cell Research Innovation Award, China Cell Biology Society Stem Cell Biology Branch.

2018, Stem Cell Achievement Transformation Award, China Cell Biology Society Stem Cell Biology Branch.

2018, First Prize of the 7th China Overseas Chinese Outstanding Contribution Award, China Federation of Returned Overseas Chinese.

2018, First Prize of China Medical Science and Technology Award, (Certificate No. 201801069P1508) 8/15.

2017, Third Prize of China Medical Science and Technology Award, (Certificate No. 201703185P0804) 4/8.

Professional Activities:

Board director, Chinese Society for Cell Biology (CSCB)

Board director, Chinese Society for Cell Biology Stem Cell Branch (CSSCR)

Member, the Society for Neuroscience (SfN)

Member, International Society for Stem Cell Research (ISSCR)

Research Grants:
Major national scientific research projects, National Natural Science Foundation Project, Key Research Program of the Chinese Academy of Sciences, "Strategic Priority Research Program" of the Chinese Academy of Sciences.

Selected Publications:
  1. J. Liu#; Z. Hou#.; J. Wu#; K. Liu; D. Li, T. Gao; W. Liu; B. An; Y. Sun; F. Mo; L. Wang; Y. Wang*; J. Hao*; B. Hu*, Infusion of hESC derived Immunity-and-matrix regulatory cells improves cognitive ability in early-stage AD mice. Cell Prolif 2021, 54 (8), e13085. DOI: 10.1111/cpr.13085.
  2. J. Wu#; D. Song#; Z. Li#; B. Guo#; Y. Xiao; W. Liu, L. Liang; C. Feng; T. Gao, Y. Chen; Y. Li, Z. Wang, J. Wen, S. Yang, P. Liu, L. Wang, Y. Wang; L. Peng; G. N. Stacey; Z. Hu, G. Feng; W. Li; Y. Huo; R. Jin, N. Shyh-Chang, Q. Zhou, L. Wang; B. Hu*; H. Dai*; J. Hao*, Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis. Cell Res 2020,  30 (9), 794-809. DOI: 10.1038/s41422-020-0354-1
  3. J. Wu; Z. Hu, L. Wang; Y. Tan; W. Hou; Z. Li; T. Gao; J. Fan; B. Guo; H. Dai; W. Li; J. Hao; R. Jin; B. Hu*, First case of COVID-19 infused with hESC derived immunity- and matrix-regulatory cells. Cell Prolif 2020,  53 (12), e12943. DOI: 10.1111/cpr.12943
  4. J. Wu#; X. Zhou#; Y. Tan#; L. Wang#; T. Li; Z. Li; T. Gao; J. Fan; B. Guo; W. Li; J. Hao*; X. Wang*; B. Hu*, Phase 1 trial for treatment of COVID-19 patients with pulmonary fibrosis using hESC-IMRCs. Cell Prolif 2020,  53 (12), e12944. DOI: 10.1111/cpr.12944
  5. F. Han; B. Hu,  Stem Cell Therapy for Parkinson's Disease. Adv Exp Med Biol 2020,  1266, 21-38 DOI: 10.1007/978-981-15-4370-8_3
  6. W. Zhu#, B. Zhang#, M. Li#, F. Mo, T. Mi, Y. Wu, Z. Teng, Q. Zhou*, W. Li*, and B. Hu*, Precisely controlling endogenous protein dosage in hPSCs and derivatives to model FOXG1 syndrome. Nat Commun, 2019. 10(1): p. 928. DOI: 10.1038/s41467-019-08841-7
  7. Y. Xu#, Y. Qiu#, B. Zhang#, G. Chen#, Q. Chen, M. Wang, F. Mo, J. Xu, J. Wu, R. Zhang, M. Cheng, N. Zhang, B. Lyu, W. Zhu, M. Wu, Q. Ye, D. Zhang, J. Man, X. Li, J. Cui, Z. Xu, B. Hu*, X. Zhou*, and C. Qin*, Zika virus infection induces RNAi-mediated antiviral immunity in human neural progenitors and brain organoids. Cell Res, 2019. 29(4): p. 265-273. DOI: 10.1038/s41422-019-0152-9
  8. L. Wang, W. Wu, Q. Gu, Z. Liu, Q. Li, Z. Li, J. Fang, W. Liu, J. Wu, Y. Zhang, L. Wang, H. Xu, W. Li, B. Hu, Q. Zhou*, Z. Yin*, and J. Hao*, The effect of clinical-grade retinal pigment epithelium derived from human embryonic stem cells using different transplantation strategies. Protein Cell, 2019. 10(6): p. 455-460. DOI: 10.1007/s13238-018-0606-8
  9. H. Sun, J. Liu, S. Li, L. Zhou, J. Wang, L. Liu*, F. Lv, Q. Gu*, B. Hu, Y. Ma*, and S. Wang*, Reactive Amphiphilic Conjugated Polymers for Inhibiting Amyloid beta Assembly. Angew Chem Int Ed Engl, 2019. 58(18): p. 5988-5993. DOI: 10.1002/anie.201901459
  10. W. Zhu, M. Li, Y. Wu, and B. Hu*, Precise immune tolerance for hPSC derivatives in clinical application. Cell Immunol, 2018. 326: p. 15-23. DOI: 10.1016/j.cellimm.2017.08.005
  11. W. Zhang#, H. Wan#, G. Feng#, J. Qu#, J. Wang, Y. Jing, R. Ren, Z. Liu, L. Zhang, Z. Chen, S. Wang, Y. Zhao, Z. Wang, Y. Yuan, Q. Zhou, W. Li*, G.H. Liu*, and B. Hu*, SIRT6 deficiency results in developmental retardation in cynomolgus monkeys. Nature, 2018. 560(7720): p. 661-665. DOI: 10.1038/s41586-018-0437-z
  12. B. Zhang#, Y. He#, Y. Xu#, F. Mo, T. Mi, Q. Shen, C. Li, Y. Li, J. Liu, Y. Wu, G. Chen, W. Zhu, C. Qin*, B. Hu*, and G. Zhou*, Differential antiviral immunity to Japanese encephalitis virus in developing cortical organoids. Cell Death Dis, 2018. 9(7): p. 719. DOI: 10.1038/s41419-018-0763-y
  13. M. Wu, D. Zhang, C. Bi, T. Mi, W. Zhu, L. Xia, Z. Teng, B. Hu*, and Y. Wu*, A Chemical Recipe for Generation of Clinical-Grade Striatal Neurons from hESCs. Stem Cell Reports, 2018. 11(3): p. 635-650. DOI: 10.1016/j.stemcr.2018.08.005
  14. Y. Wang#, W. Zhu#, M. Wu#, Y. Wu, Z. Liu, L. Liang, C. Sheng, J. Hao, L. Wang, W. Li, Q. Zhou*, B. Hu*, Human Clinical-Grade Parthenogenetic ESC-Derived Dopaminergic Neurons Recover Locomotive Defects of Nonhuman Primate Models of Parkinson's Disease. Stem Cell Reports, 2018. 11(1): p. 171-182. DOI: 10.1016/j.stemcr.2018.05.010
  15. X. #Wang, T. Li#, T. Cui#, D. Yu#, C. Liu#, L. Jiang, G. Feng, L. Wang, R. Fu, X. Zhang, J. Hao, Y. Wang, L. Wang, Q. Zhou*, W. Li*, and B. Hu*, Human embryonic stem cells contribute to embryonic and extraembryonic lineages in mouse embryos upon inhibition of apoptosis. Cell Res, 2018. 28(1): p. 126-129. DOI: 10.1038/cr.2017.138
  16. Y. Tan#, P. Han#, Q. Gu#, G. Chen, L. Wang, R. Ma, J. Wu, C. Feng, Y. Zhang, L. Wang, B. Hu, W. Li, J. Hao*, and Q. Zhou*, Generation of clinical-grade functional cardiomyocytes from human embryonic stem cells in chemically defined conditions. J Tissue Eng Regen Med, 2018. 12(1): p. 153-163. DOI: 10.1002/term.2381
  17. Z. Li#, L. Wang#, L. Wang#, G. Feng#, X. Yuan#, C. Liu, K. Xu, Y. Li, H. Wan, Y. Zhang, Y. Li, X. Li, W. Li*, Q. Zhou*, B. Hu*, Generation of Bimaternal and Bipaternal Mice from Hypomethylated Haploid ESCs with Imprinting Region Deletions. Cell Stem Cell, 2018. 23(5): p. 665-676 e4. DOI: 10.1016/j.stem.2018.09.004
  18. X. Li#, R. Ma#, Q. Gu#, L. Liang, L. Wang, Y. Zhang, X. Wang, X. Liu, Z. Li, J. Fang, J. Wu, Y. Wang, W. Li, B. Hu, L. Wang*, Q. Zhou*, and J. Hao*, A fully defined static suspension culture system for large-scale human embryonic stem cell production. Cell Death Dis, 2018. 9(9): p. 892. DOI: 10.1038/s41419-018-0863-8
  19. Y. Jiang#, L. Yan#, L. Xia, X. Lu, W. Zhu, D. Ding, M. Du, D. Zhang, H. Wang*, and B. Hu*, Zinc finger E-box-binding homeobox 1 (ZEB1) is required for neural differentiation of human embryonic stem cells. J Biol Chem, 2018. 293(50): p. 19317-19329. DOI: 10.1074/jbc.RA118.005498
  20. G. Chen#, D. Zhang#, L. Zhang#, G. Feng, B. Zhang, Y. Wu, W. Li, Y. Zhang*, and B. Hu*, RBM14 is indispensable for pluripotency maintenance and mesoderm development of mouse embryonic stem cells. Biochem Biophys Res Commun, 2018. 501(1): p. 259-265. DOI: 10.1016/j.bbrc.2018.04.231
  21. L. Yuan#, X. Huang#, Z. Liu#, F. Zhang#, X. Zhu#, J. Yu#, X. Ji, Y.P. Xu, G. Li, C. Li, H. Wang, Y. Deng, M. Wu, M. Cheng, Q. Ye, D. Xie, X. Li, X. Wang, W. Shi, B. Hu, P.Y. Shi, Z. Xu*, and C. Qin*, A single mutation in the prM protein of Zika virus contributes to fetal microcephaly. Science, 2017. 358(6365): p. 933-936. DOI: 10.1126/science.aam7120
  22. L. Yan#, Y. Li#, Z. Shi#, X. Lu#, J. Ma, B. Hu, J. Jiao*, and H. Wang*, The zinc finger E-box-binding homeobox 1 (Zeb1) promotes the conversion of mouse fibroblasts into functional neurons. J Biol Chem, 2017. 292(31): p. 12959-12970. DOI: 10.1074/jbc.M116.771493
  23. K. Qian#, H. Huang#, A. Peterson, B. Hu, N.J. Maragakis, G.L. Ming, H. Chen*, and S.C. Zhang*, Sporadic ALS Astrocytes Induce Neuronal Degeneration In Vivo. Stem Cell Reports, 2017. 8(4): p. 843-855. DOI: 10.1016/j.stemcr.2017.03.003
  24. P. Liu#, K. Liu#, H. Gu, W. Wang, J. Gong, Y. Zhu, Q. Zhao, J. Cao, C. Han, F. Gao, Q. Chen, W. Li, J. Jiao, B. Hu, Q. Zhou, and T. Zhao*, High autophagic flux guards ESC identity through coordinating autophagy machinery gene program by FOXO1. Cell Death Differ, 2017. 24(10): p. 1672-1680. DOI: 10.1038/cdd.2017.90
  25. T. Li#, G. Feng#, Y. Li#, M. Wang#, J. Mao, J. Wang, X. Li, X. Wang, B. Qu, L.Y. Wang, X. Zhang, H. Wan, T. Cui, C. Wan, L. Liu, X. Zhao, B. Hu, W. Li, and Q. Zhou*, Rat embryonic stem cells produce fertile offspring through tetraploid complementation. Proc Natl Acad Sci U S A, 2017. 114(45): p. 11974-11979. DOI: 10.1073/pnas.1708710114
  26. Q. Gu#, J. Wang#, L. Wang#, Z. Liu, W. Zhu, Y. Tan, W. Han, J. Wu, C. Feng, J. Fang, L. Liu, L. Wang, W. Li, X. Zhao, B. Hu, J. Hao*, and Q. Zhou*, Accreditation of Biosafe Clinical-Grade Human Embryonic Stem Cells According to Chinese Regulations. Stem Cell Reports, 2017. 9(1): p. 366-380. DOI: 10.1016/j.stemcr.2017.04.017
  27. J. Zhang#, S. Chen#, D. Zhang, Z. Shi, H. Li, T. Zhao, B. Hu, Q. Zhou, and J. Jiao*, Tet3-Mediated DNA Demethylation Contributes to the Direct Conversion of Fibroblast to Functional Neuron. Cell Rep, 2016. 17(9): p. 2326-2339. DOI: 10.1016/j.celrep.2016.10.081
  28. C. Zhang, J. Cao, X. Li, H. Xu, W. Wang, L. Wang, X. Zhao, W. Li, J. Jiao, B. Hu, Q. Zhou*, and T. Zhao*, Treatment of multiple sclerosis by transplantation of neural stem cells derived from induced pluripotent stem cells. Sci China Life Sci, 2016. 59(9): p. 950-7. DOI: 10.1007/s11427-016-0114-9
  29. Z. Shi, J. Zhang, S. Chen, Y. Li, X. Lei, H. Qiao, Q. Zhu, B. Hu, Q. Zhou, and J. Jiao*, Conversion of Fibroblasts to Parvalbumin Neurons by One Transcription Factor, Ascl1, and the Chemical Compound Forskolin. J Biol Chem, 2016. 291(26): p. 13560-70. DOI: 10.1074/jbc.M115.709808
  30. K. Liu#, Q. Zhao#, P. Liu#, J. Cao, J. Gong, C. Wang, W. Wang, X. Li, H. Sun, C. Zhang, Y. Li, M. Jiang, S. Zhu, Q. Sun, J. Jiao, B. Hu, X. Zhao, W. Li, Q. Chen, Q. Zhou*, and T. Zhao*, ATG3-dependent autophagy mediates mitochondrial homeostasis in pluripotency acquirement and maintenance. Autophagy, 2016. 12(11): p. 2000-2008. DOI: 10.1080/15548627.2016.1212786
  31. Z. Li#, H. Wan#, G. Feng#, L. Wang#, Z. He, Y. Wang, X.J. Wang, W. Li*, Q. Zhou*, and B. Hu*, Birth of fertile bimaternal offspring following intracytoplasmic injection of parthenogenetic haploid embryonic stem cells. Cell Res, 2016. 26(1): p. 135-8. DOI: 10.1038/cr.2015.151
  32. Y. Jiang#, M. Du#, M. Wu, Y. Zhu, X. Zhao, X. Cao, X. Li, P. Long, W. Li*, and B. Hu*, Phosphatidic Acid Improves Reprogramming to Pluripotency by Reducing Apoptosis. Stem Cells Dev, 2016. 25(1): p. 43-54. DOI: 10.1089/scd.2015.0159
  33. L. Gao, Y. Zhang, B. Hu, J. Liu, P. Kong, S. Lou, Y. Su, T. Yang, H. Li, Y. Liu, C. Zhang, L. Gao, L. Zhu, Q. Wen, P. Wang, X. Chen, J. Zhong, and X. Zhang*, Phase II Multicenter, Randomized, Double-Blind Controlled Study of Efficacy and Safety of Umbilical Cord-Derived Mesenchymal Stromal Cells in the Prophylaxis of Chronic Graft-Versus-Host Disease After HLA-Haploidentical Stem-Cell Transplantation. J Clin Oncol, 2016. 34(24): p. 2843-50. DOI: 10.1200/JCO.2015.65.3642
  34. H. Zhu#, Y. Tan#, Q. Gu, W. Han, Z. Li, J. S. Meyer*, and B. Hu*, Regulations in the United States for cell transplantation clinical trials in neurological diseases. Translational Neuroscience and Clinics, 2015. 1(2): p. 114-124. DOI: 10.18679/cn11-6030/r.2015.015
  35. L. Wang#, J. Cao#, Y. Wang#, T. Lan#, L. Liu, W. Wang, N. Jin, J. Gong, C. Zhang, F. Teng, G. Yan, C. Li, J. Li, H. Wan, B. Hu, W. Li, X. Zhao, Z. Qi*, T. Zhao*, and Q. Zhou*, Immunogenicity and functional evaluation of iPSC-derived organs for transplantation. Cell Discov, 2015. 1: p. 15015. DOI: 10.1038/celldisc.2015.15
  36. H. Wan#, C. Feng#, F. Teng#, S. Yang#, B. Hu, Y. Niu, A.P. Xiang, W. Fang, W. Ji, W. Li*, X. Zhao*, and Q. Zhou*, One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system. Cell Res, 2015. 25(2): p. 258-61. DOI: 10.1038/cr.2014.158
  37. W. Shi#, L.I. Zhu#, Y. Wang, B. Hu, H. Xiao, G. Zhou, and C. Chen*, Estrogen therapy to treat retinopathy in newborn mice. Exp Ther Med, 2015. 10(2): p. 611-617. DOI: 10.3892/etm.2015.2554
  38. H. Chen*, K. Qian, W. Chen, B. Hu, L.W.t. Blackbourn, Z. Du, L. Ma, H. Liu, K.M. Knobel, M. Ayala, and S.C. Zhang*, Human-derived neural progenitors functionally replace astrocytes in adult mice. J Clin Invest, 2015. 125(3): p. 1033-42. DOI: 10.1172/JCI69097
  39. S. Wang, W. Li, S. Wang, and B. Hu*, Rapid and efficient assembly of transcription activator-like effector genes by USER cloning. J Genet Genomics, 2014. 41(6): p. 339-47. DOI: 10.1016/j.jgg.2014.05.002
  40. L. Cong, H. Xiao, B. Hu*, and G. Zhou*, Drastic alleviation of neovascularization in oxygen induced retinopathy of mice following intravitreal bone marrow stromal cell transplantation. Chinese Journal of Neuroanatomy, 2014. 30(3): p. 249-260.
  41. M. Wu, G. Chen, and B. Hu*, Induced pluripotency for translational research. Genomics Proteomics Bioinformatics, 2013. 11(5): p. 288-93. DOI: 10.1016/j.gpb.2013.08.001
  42. L. Ma, B. Hu, Y. Liu, S.C. Vermilyea, H. Liu, L. Gao, Y. Sun, X. Zhang, and S.C. Zhang*, Human embryonic stem cell-derived GABA neurons correct locomotion deficits in quinolinic acid-lesioned mice. Cell Stem Cell, 2012. 10(4): p. 455-64. DOI: 10.1016/j.stem.2012.01.021
  43. Y. Jiang, M. Zhang, B. Hu*, Specification of functional neurons and glia from human pluripotent stem cells. Protein Cell, 2012. 3(11): p. 818-25. DOI: 10.1007/s13238-012-2086-6
  44. J. Hao, D. Campagnolo, R. Liu, W. Piao, S. Shi, B. Hu, R. Xiang, Q. Zhou, T. Vollmer, L. Van Kaer, A. La Cava, and F.D. Shi*, Interleukin-2/interleukin-2 antibody therapy induces target organ natural killer cells that inhibit central nervous system inflammation. Ann Neurol, 2011. 69(4): p. 721-34. DOI: 10.1002/ana.22339
  45. B. Hu and S. Zhang, Directed Differentiation of Neural-stem cells and Subtype-Specific Neurons from hESCs, in Cellular Programming and Reprogramming: Methods and Protocols, S. Ding, Editor. 2010, Humana Press: Totowa, NJ. p. 123-137.
  46. B. Hu, J. Weick, J. Yu, L. Ma, X. Zhang, J. Thomson, and S. Zhang*, Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency. Proc Natl Acad Sci U S A, 2010. 107(9): p. 4335-40. DOI: 10.1073/pnas.0910012107
  47. B. Hu and S. Zhang*, Differentiation of spinal motor neurons from pluripotent human stem cells. Nat Protoc, 2009. 4(9): p. 1295-304. DOI: 10.1038/nprot.2009.127
  48. B. Hu, Z. Du, and S. Zhang*, Differentiation of human oligodendrocytes from pluripotent stem cells. Nat Protoc, 2009. 4(11): p. 1614-22. DOI: 10.1038/nprot.2009.186
  49. B. Hu#, Z. Du#, X. Li, M. Ayala, and S. Zhang*, Human oligodendrocytes from embryonic stem cells: conserved SHH signaling networks and divergent FGF effects. Development, 2009. 136(9): p. 1443-52. DOI: 10.1242/dev.029447
  50. Z. Du, B. Hu, M. Ayala, B. Sauer, and S. Zhang*, Cre recombination-mediated cassette exchange for building versatile transgenic human embryonic stem cells lines. Stem Cells, 2009. 27(5): p. 1032-41. DOI: 10.1002/stem.38
  51. X. Li, B. Hu, S. Jones, Y. Zhang, T. Lavaute, Z. Du, and S. Zhang*, Directed differentiation of ventral spinal progenitors and motor neurons from human embryonic stem cells by small molecules. Stem Cells, 2008. 26(4): p. 886-93. DOI: 10.1634/stemcells.2007-0620

Notes:  # These authors contributed equally; * Correspondence.

  1. Zhang SC, Hu BY, Du ZW. Myelinating Oligodendrocyte Precursor Populations, US patent, 2014: US 8658424 B2.
  2. Zhang SC, Hu BY, Du ZW. Method of Generating Myelinating Oligodendrocytes from Embryonic Stem Cells, US patent, 2012: US 8227247 B2.
  3. Jiang Y, Du MX, Hu BY. Culture medium and method for increasing somatic cell reprogramming efficiency, CN patent, 2019: ZL201510528329.X
  4. Wang S, Hu BY, Construction method for TALE repeated sequence vector, CN patent, 2020: ZL201610266044.8