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  Principal Investigators
HU Baoyang
Stem Cell Biology and Regenerative Medicine
+86-10-64806251  / 
Institute of Zoology, Chinese Academy of Siences,C107-1, 1 Beichen West Road, Chaoyang District, Beijing 100101, P.R.China
Hu's Group      

Baoyang Hu is a Professor of Stem Cell and Regenerative Biology at the Institute of Zoology (IOZ), Chinese academy of Sciences (CAS), known for his work in neural differentiation from human pluripotent stem cells. He was appointed the deputy director of State Key Laboratory of Stem Cell and Reproductive Biology in 2015, and the Vice President of the Savaid Medical School at the University of the Chinese Academy of Sciences in 2016.

Dr. Hu got his medical degree from the Jining Medical University in 1995, where he spent another 4 years teaching Anatomy before going to the Fudan University for his Ph. D. degree in Embryology. In 2004, Hu went to Dr. Su-Chun Zhang's stem cell research lab at the University of Wisconsin-Madison working on on neural differentiation. He joined the Institute of Zoology at the Chinese Academy of Sciences in 2011 through the "One Hundred Talents Program".

Dr. Hu has differentiated the human embryonic stem cells (hESC) into functional neurons and glia for cure of diseases such as stroke, Parkinson's disease and motor neuron diseases. He has published a series of papers on prestigious journals such as Cell Stem Cells, PNAS, Cell Research and Development. Dr. Hu and his team will continue to explore the molecular mechanisms of neural differentiation and the uniqueness of human biology. Using a lately developed protocol of cerebral organoid culture from hPSCs, they will discover the mechanisms of an evolutionary enlarged and gyrified human brain. This will allow them to develop protocols for massively production of functional human cells, either through directed differentiation from PSCs or by direct conversion from other types of somatic cells. They will also dedicate to translating the stem cell research into application by accredation of these cells for treating relevant neurological diseases.

Research Interests:
Neural differentiation and translational stem cell research.

Awards and Honors:
Awardee, “100 Talents Program”, CAS.

Professional Activities:
Director, Chinese Society for Cell Biology Stem Cell Branch
Member, the Society for Neuroscience (SfN)
Member, International Society for Stem Cell Research (ISSCR)

Research Grants:
Major national scientific research projects, Key Research Program of the Chinese Academy of Sciences, "Strategic Priority Research Program" of the Chinese Academy of Sciences, National Natural Science Foundation Project.

Selected Publications:
  1. Wang X, Li T, Cui T, Yu D, Liu C, Jiang L, Feng G, Wang L, Fu R, Zhang X, Hao J, Wang Y, Wang L, Zhou Q, Li W, Hu B. Human embryonic stem cells contribute to embryonic and extraembryonic lineages in mouse embryos upon inhibition of apoptosis. Cell research (2017).
  2. Zhu W, Li M, Wu Y, Hu B. Precise immune tolerance for hPSC derivatives in clinical application. Cellular immunology (2017).
  3. Yuan L, Huang X, Liu Z, Zhang F, Zhu X, Yu J, Ji X, Xu Y, Li G, Li C, Wang H, Deng Y, Wu M, Cheng M, Ye Q, Xie D, Li X, Wang X, Shi W, Hu B, Shi P, Xu Z, Qin Cl. A single mutation in the prM protein of Zika virus contributes to fetal microcephaly. Science 358(2017), 933-936.
  4. Li T, Feng G, Li Y, Wang M, Mao J, Wang J, Li X, Wang X, Qu B, Wang L, Zhang X, Wan H, Cui T, Wan C, Liu L, Zhao X, Hu B, Li W, Zhou Q. Rat embryonic stem cells produce fertile offspring through tetraploid complementation. Proceedings of the National Academy of Sciences of the United States of America 114(2017), 11974-11979.
  5. Li Z, Wan H, Feng G, Wang L, He Z, Wang Y, Wang X, Li W, Zhou Q, Hu B. Birth of fertile bimaternal offspring following intracytoplasmic injection of parthenogenetic haploid embryonic stem cells. Cell research 26(2016), 135-138.
  6. Jiang Y, Du M, Wu M, Zhu Y, Zhao X, Cao X, Li X, Long P, Li W, Hu B. Phosphatidic Acid Improves Reprogramming to Pluripotency by Reducing Apoptosis. Stem cells and development 25(2016), 43-54.
  7. Gao L, Zhang Y, Hu B, Liu J, Kong P, Lou S, Su Y, Yang T, Li H, Liu, Y, Zhang C, Gao L, Zhu L, Wen Q, Wang P, Chen X, Zhong J, Zhang X. Phase II Multicenter, Randomized, Double-Blind Controlled Study of Efficacy and Safety of Umbilical Cord-Derived Mesenchymal Stromal Cells in the Prophylaxis of Chronic Graft-Versus-Host Disease After HLA-Haploidentical Stem-Cell Transplantation. Journal of Clinical Oncology 34(2016), 2843-2850.
  8. Wan H, Feng C, Teng F, Yang S, Hu B, Niu Y, Xiang A, Fang W, Ji W, Li W, Zhao X, Zhou Q. One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system. Cell research 25(2015), 258-261.
  9. Zhu H, Tan Y, Gu Q, Han W, Li Z, Meyer J, Hu B. Regulations in the United States for cell transplantation clinical trials in neurological diseases. Translational Neuroscience and Clinics. 1(2015), 114-124.
  10. Chen H, Qian K, Chen W, Hu B, Blackbourn L, Du Z, Ma L, Liu H, Knobel K, Ayala M, Zhang S. Human-derived neural progenitors functionally replace astrocytes in adult mice. The Journal of clinical investigation 125(2015), 1033-1042.
  11. Wang S, Li W, Wang S, Hu B. Rapid and efficient assembly of transcription activator-like effector genes by USER cloning. Journal of genetics and genomics 41(2014), 339-347.
  12. Wu M, Chen G, Hu B. Induced pluripotency for translational research. Genomics, proteomics & bioinformatics 11(2013), 288-293.
  13. Jiang Y, Zhang M, Hu B. Specification of functional neurons and glia from human pluripotent stem cells. Protein & cell 3(2012), 818-825.
  14. Ma L, Hu B, Liu Y, Vermilyea S, Liu H, Gao L, Sun Y, Zhang X, Zhang S. Human embryonic stem cell-derived GABA neurons correct locomotion deficits in quinolinic acid-lesioned mice. Cell stem cell 10(2012), 455-464.
  15. Hu B, Zhang S. Directed differentiation of neural-stem cells and subtype-specific neurons from hESCs. Methods in molecular biology 636(2010), 123-137.
  16. Hu B, Weick J, Yu J, Ma L, Zhang X, Thomson J, Zhang S. Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency. Proceedings of the National Academy of Sciences of the United States of America 107(2010), 4335-4340.
  17. Hu B, Zhang S. Differentiation of spinal motor neurons from pluripotent human stem cells. Nature protocols 4(2009), 1295-1304.
  18. Hu B, Du Z, Zhang S. Differentiation of human oligodendrocytes from pluripotent stem cells. Nature protocols 4(2009b), 1614-1622.
  19. Hu B, Du Z, Li X, Ayala M, Zhang S. Human oligodendrocytes from embryonic stem cells: conserved SHH signaling networks and divergent FGF effects. Development 136(2009a), 1443-1452.
  20. Du Z, Hu B, Ayala M, Sauer B, Zhang S. Cre recombination-mediated cassette exchange for building versatile transgenic human embryonic stem cells lines. Stem cells 27(2009), 1032-1041.
  21. Li X, Hu B, Jones S, Zhang Y, Lavaute T, Du Z, Zhang S. Directed differentiation of ventral spinal progenitors and motor neurons from human embryonic stem cells by small molecules. Stem cells 26(2008), 886-893.
  1. Zhang SC, Hu BY, Du ZW. Myelinating Oligodendrocyte Precursor Populations, US patent, 2014: US 8658424 B2.
  2. Zhang SC, Hu BY, Du ZW. Method of Generating Myelinating Oligodendrocytes from Embryonic Stem Cells, US patent, 2012: US 8227247 B2.