姓  名: 胡宝洋
学  科: 干细胞与再生医学
电话/传真: +86-10-64806251 / 
电子邮件: byhu@ioz.ac.cn
通讯地址: 北京市朝阳区北辰西路1号院5号 中国科学院动物研究所 C107-1 100101
更多信息: 干细胞与神经再生研究组     

简历介绍:

  胡宝洋,博士、研究员,中国科学院“百人计划”入选者。现任中国科学院干细胞与再生医学创新研究院(筹)执行院长,中国科学院大学医学院常务副院长,干细胞与生殖生物学国家重点实验室副主任。
  2004年获复旦大学博士学位,2005年赴美国威斯康星大学(University of Wisconsin-Madison)从事博士后研究,2009年任助理科学家(Assistant Scientist),2011年1月加入中国科学院动物研究所。
  主要从事干细胞与再生医学研究。重点关注脑发育与疾病、干细胞分化及临床应用等问题,围绕脑发育及调控的进化特性、神经系定向分化机理、分化细胞的临床应用等方面取得系列重要成果。带领团队首次发现人iPS神经分化的异质性及规律(PNAS, 2010);首次获得SIRT6敲除猴并揭示其调控和进化特性(Nature, 2018);率先推动人胚干细胞分化细胞治疗帕金森病等临床研究。
  承担科技部、国家自然科学基金委、中国科学院、北京市等多项科研任务,在Nature、Science、Cell Stem Cell、PNAS、Cell Research等期刊发表高水平论文40余篇,获美国专利2项。 担任多种国际学术期刊审阅人,多次应邀参加国际、国内学术交流。兼任国家重大研发计划干细胞与转化研究重点专项专家组副组长,中国细胞生物学学会常务理事、干细胞分会理事等。
  目前在读研究生和联合培养研究生18名。已出站博士后3名,毕业博士研究生7名,硕士研究生7名。 

研究领域:

  主要从事干细胞与再生医学领域的研究,重点研究全能干细胞向神经系的分化机制、人类干细胞生物学的独特性以及干细胞医药学应用的系统化评估等科学问题。
  1. 神经分化机制。用多能干细胞定向分化和细胞重编程为模型,研究神经分化中细胞外信号、转录程序、转录前后表观遗传学因素如何协同指导多能干细胞向某一特定类型细胞分化。借助小鼠等动物模型和遗传学手段在体内进一步验证。
  2. 人类发育和细胞分化的独特性。以人多能干细胞神经定向分化系统为基础,综合利用多种手段发掘决定人类高级功能和独特性状的调控元件及调控机制。
  3. 干细胞医学转化。以定向分化为基础,完善规模化细胞分化和体细胞直接转分化为特定细胞类型的方法。与相关领域合作,建立细胞产品应用于细胞替代和药物筛选的标准评估体系。

社会任职:

  中国细胞生物学学会干细胞分会理事,国际干细胞研究学会(ISSCR)会员,美国神经科学学会(SfN)会员。

获奖及荣誉:

  • 干细胞成果转化奖(2018),中国细胞生物学会干细胞生物学分会
  • 第七届中国侨届杰出贡献奖一等奖(2018),中国侨联
  • 中华医学科技奖一等奖(2018) (证书号201801069P1508) 8/15
  • 中华医学科技奖三等奖(2017) (证书号201703185P0804) 4/8
  • 中国科学院“百人计划”引进国外杰出人才(2012)

承担科研项目情况:

   国家重大科学研究计划项目,中国科学院重点部署项目,中国科学院战略性先导科技专项,国家自然科学基金项目等。

代表论著:

  1. W. Zhu#, B. Zhang#, M. Li#, F. Mo, T. Mi, Y. Wu, Z. Teng, Q. Zhou*, W. Li*, and B. Hu*, Precisely controlling endogenous protein dosage in hPSCs and derivatives to model FOXG1 syndrome. Nat Commun, 2019. 10(1): p. 928. DOI: 10.1038/s41467-019-08841-7
  2. Y.P. Xu#, Y. Qiu#, B. Zhang#, G. Chen#, Q. Chen, M. Wang, F. Mo, J. Xu, J. Wu, R.R. Zhang, M.L. Cheng, N.N. Zhang, B. Lyu, W.L. Zhu, M.H. Wu, Q. Ye, D. Zhang, J.H. Man, X.F. Li, J. Cui, Z. Xu, B. Hu*, X. Zhou*, and C.F. Qin*, Zika virus infection induces RNAi-mediated antiviral immunity in human neural progenitors and brain organoids. Cell Res, 2019. 29(4): p. 265-273. DOI: 10.1038/s41422-019-0152-9
  3. L. Wang, W. Wu, Q. Gu, Z. Liu, Q. Li, Z. Li, J. Fang, W. Liu, J. Wu, Y. Zhang, L. Wang, H. Xu, W. Li, B. Hu, Q. Zhou*, Z. Yin*, and J. Hao*, The effect of clinical-grade retinal pigment epithelium derived from human embryonic stem cells using different transplantation strategies. Protein Cell, 2019. 10(6): p. 455-460. DOI: 10.1007/s13238-018-0606-8
  4. H. Sun, J. Liu, S. Li, L. Zhou, J. Wang, L. Liu*, F. Lv, Q. Gu*, B. Hu, Y. Ma*, and S. Wang*, Reactive Amphiphilic Conjugated Polymers for Inhibiting Amyloid beta Assembly. Angew Chem Int Ed Engl, 2019. 58(18): p. 5988-5993. DOI: 10.1002/anie.201901459
  5. W. Zhu, M. Li, Y. Wu, and B. Hu*, Precise immune tolerance for hPSC derivatives in clinical application. Cell Immunol, 2018. 326: p. 15-23. DOI: 10.1016/j.cellimm.2017.08.005
  6. W. Zhang#, H. Wan#, G. Feng#, J. Qu#, J. Wang, Y. Jing, R. Ren, Z. Liu, L. Zhang, Z. Chen, S. Wang, Y. Zhao, Z. Wang, Y. Yuan, Q. Zhou, W. Li*, G.H. Liu*, and B. Hu*, SIRT6 deficiency results in developmental retardation in cynomolgus monkeys. Nature, 2018. 560(7720): p. 661-665. DOI: 10.1038/s41586-018-0437-z
  7. B. Zhang#, Y. He#, Y. Xu#, F. Mo, T. Mi, Q.S. Shen, C. Li, Y. Li, J. Liu, Y. Wu, G. Chen, W. Zhu, C. Qin*, B. Hu*, and G. Zhou*, Differential antiviral immunity to Japanese encephalitis virus in developing cortical organoids. Cell Death Dis, 2018. 9(7): p. 719. DOI: 10.1038/s41419-018-0763-y
  8. M. Wu, D. Zhang, C. Bi, T. Mi, W. Zhu, L. Xia, Z. Teng, B. Hu*, and Y. Wu*, A Chemical Recipe for Generation of Clinical-Grade Striatal Neurons from hESCs. Stem Cell Reports, 2018. 11(3): p. 635-650. DOI: 10.1016/j.stemcr.2018.08.005
  9. Y.K. Wang#, W.W. Zhu#, M.H. Wu#, Y.H. Wu, Z.X. Liu, L.M. Liang, C. Sheng, J. Hao, L. Wang, W. Li, Q. Zhou*, and B.Y. Hu*, Human Clinical-Grade Parthenogenetic ESC-Derived Dopaminergic Neurons Recover Locomotive Defects of Nonhuman Primate Models of Parkinson's Disease. Stem Cell Reports, 2018. 11(1): p. 171-182. DOI: 10.1016/j.stemcr.2018.05.010
  10. X. #Wang, T. Li#, T. Cui#, D. Yu#, C. Liu#, L. Jiang, G. Feng, L. Wang, R. Fu, X. Zhang, J. Hao, Y. Wang, L. Wang, Q. Zhou*, W. Li*, and B. Hu*, Human embryonic stem cells contribute to embryonic and extraembryonic lineages in mouse embryos upon inhibition of apoptosis. Cell Res, 2018. 28(1): p. 126-129. DOI: 10.1038/cr.2017.138
  11. Y. Tan#, P. Han#, Q. Gu#, G. Chen, L. Wang, R. Ma, J. Wu, C. Feng, Y. Zhang, L. Wang, B. Hu, W. Li, J. Hao*, and Q. Zhou*, Generation of clinical-grade functional cardiomyocytes from human embryonic stem cells in chemically defined conditions. J Tissue Eng Regen Med, 2018. 12(1): p. 153-163. DOI: 10.1002/term.2381
  12. Z.K. Li#, L.Y. Wang#, L.B. Wang#, G.H. Feng#, X.W. Yuan#, C. Liu, K. Xu, Y.H. Li, H.F. Wan, Y. Zhang, Y.F. Li, X. Li, W. Li*, Q. Zhou*, and B.Y. Hu*, Generation of Bimaternal and Bipaternal Mice from Hypomethylated Haploid ESCs with Imprinting Region Deletions. Cell Stem Cell, 2018. 23(5): p. 665-676 e4. DOI: 10.1016/j.stem.2018.09.004
  13. X. Li#, R. Ma#, Q. Gu#, L. Liang, L. Wang, Y. Zhang, X. Wang, X. Liu, Z. Li, J. Fang, J. Wu, Y. Wang, W. Li, B. Hu, L. Wang*, Q. Zhou*, and J. Hao*, A fully defined static suspension culture system for large-scale human embryonic stem cell production. Cell Death Dis, 2018. 9(9): p. 892. DOI: 10.1038/s41419-018-0863-8
  14. Y. Jiang#, L. Yan#, L. Xia, X. Lu, W. Zhu, D. Ding, M. Du, D. Zhang, H. Wang*, and B. Hu*, Zinc finger E-box-binding homeobox 1 (ZEB1) is required for neural differentiation of human embryonic stem cells. J Biol Chem, 2018. 293(50): p. 19317-19329. DOI: 10.1074/jbc.RA118.005498
  15. G. Chen#, D. Zhang#, L. Zhang#, G. Feng, B. Zhang, Y. Wu, W. Li, Y. Zhang*, and B. Hu*, RBM14 is indispensable for pluripotency maintenance and mesoderm development of mouse embryonic stem cells. Biochem Biophys Res Commun, 2018. 501(1): p. 259-265. DOI: 10.1016/j.bbrc.2018.04.231
  16. L. Yuan#, X.Y. Huang#, Z.Y. Liu#, F. Zhang#, X.L. Zhu#, J.Y. Yu#, X. Ji, Y.P. Xu, G. Li, C. Li, H.J. Wang, Y.Q. Deng, M. Wu, M.L. Cheng, Q. Ye, D.Y. Xie, X.F. Li, X. Wang, W. Shi, B. Hu, P.Y. Shi, Z. Xu*, and C.F. Qin*, A single mutation in the prM protein of Zika virus contributes to fetal microcephaly. Science, 2017. 358(6365): p. 933-936. DOI: 10.1126/science.aam7120
  17. L. Yan#, Y. Li#, Z. Shi#, X. Lu#, J. Ma, B. Hu, J. Jiao*, and H. Wang*, The zinc finger E-box-binding homeobox 1 (Zeb1) promotes the conversion of mouse fibroblasts into functional neurons. J Biol Chem, 2017. 292(31): p. 12959-12970. DOI: 10.1074/jbc.M116.771493
  18. K. Qian#, H. Huang#, A. Peterson, B. Hu, N.J. Maragakis, G.L. Ming, H. Chen*, and S.C. Zhang*, Sporadic ALS Astrocytes Induce Neuronal Degeneration In Vivo. Stem Cell Reports, 2017. 8(4): p. 843-855. DOI: 10.1016/j.stemcr.2017.03.003
  19. P. Liu#, K. Liu#, H. Gu, W. Wang, J. Gong, Y. Zhu, Q. Zhao, J. Cao, C. Han, F. Gao, Q. Chen, W. Li, J. Jiao, B. Hu, Q. Zhou, and T. Zhao*, High autophagic flux guards ESC identity through coordinating autophagy machinery gene program by FOXO1. Cell Death Differ, 2017. 24(10): p. 1672-1680. DOI: 10.1038/cdd.2017.90
  20. T.D. Li#, G.H. Feng#, Y.F. Li#, M. Wang#, J.J. Mao, J.Q. Wang, X. Li, X.P. Wang, B. Qu, L.Y. Wang, X.X. Zhang, H.F. Wan, T.T. Cui, C. Wan, L. Liu, X.Y. Zhao, B.Y. Hu, W. Li, and Q. Zhou*, Rat embryonic stem cells produce fertile offspring through tetraploid complementation. Proc Natl Acad Sci U S A, 2017. 114(45): p. 11974-11979. DOI: 10.1073/pnas.1708710114
  21. Q. Gu#, J. Wang#, L. Wang#, Z.X. Liu, W.W. Zhu, Y.Q. Tan, W.F. Han, J. Wu, C.J. Feng, J.H. Fang, L. Liu, L. Wang, W. Li, X.Y. Zhao, B.Y. Hu, J. Hao*, and Q. Zhou*, Accreditation of Biosafe Clinical-Grade Human Embryonic Stem Cells According to Chinese Regulations. Stem Cell Reports, 2017. 9(1): p. 366-380. DOI: 10.1016/j.stemcr.2017.04.017
  22. J. Zhang#, S. Chen#, D. Zhang, Z. Shi, H. Li, T. Zhao, B. Hu, Q. Zhou, and J. Jiao*, Tet3-Mediated DNA Demethylation Contributes to the Direct Conversion of Fibroblast to Functional Neuron. Cell Rep, 2016. 17(9): p. 2326-2339. DOI: 10.1016/j.celrep.2016.10.081
  23. C. Zhang, J. Cao, X. Li, H. Xu, W. Wang, L. Wang, X. Zhao, W. Li, J. Jiao, B. Hu, Q. Zhou*, and T. Zhao*, Treatment of multiple sclerosis by transplantation of neural stem cells derived from induced pluripotent stem cells. Sci China Life Sci, 2016. 59(9): p. 950-7. DOI: 10.1007/s11427-016-0114-9
  24. Z. Shi, J. Zhang, S. Chen, Y. Li, X. Lei, H. Qiao, Q. Zhu, B. Hu, Q. Zhou, and J. Jiao*, Conversion of Fibroblasts to Parvalbumin Neurons by One Transcription Factor, Ascl1, and the Chemical Compound Forskolin. J Biol Chem, 2016. 291(26): p. 13560-70. DOI: 10.1074/jbc.M115.709808
  25. K. Liu#, Q. Zhao#, P. Liu#, J. Cao, J. Gong, C. Wang, W. Wang, X. Li, H. Sun, C. Zhang, Y. Li, M. Jiang, S. Zhu, Q. Sun, J. Jiao, B. Hu, X. Zhao, W. Li, Q. Chen, Q. Zhou*, and T. Zhao*, ATG3-dependent autophagy mediates mitochondrial homeostasis in pluripotency acquirement and maintenance. Autophagy, 2016. 12(11): p. 2000-2008. DOI: 10.1080/15548627.2016.1212786
  26. Z. Li#, H. Wan#, G. Feng#, L. Wang#, Z. He, Y. Wang, X.J. Wang, W. Li*, Q. Zhou*, and B. Hu*, Birth of fertile bimaternal offspring following intracytoplasmic injection of parthenogenetic haploid embryonic stem cells. Cell Res, 2016. 26(1): p. 135-8. DOI: 10.1038/cr.2015.151
  27. Y. Jiang#, M. Du#, M. Wu, Y. Zhu, X. Zhao, X. Cao, X. Li, P. Long, W. Li*, and B. Hu*, Phosphatidic Acid Improves Reprogramming to Pluripotency by Reducing Apoptosis. Stem Cells Dev, 2016. 25(1): p. 43-54. DOI: 10.1089/scd.2015.0159
  28. L. Gao, Y. Zhang, B. Hu, J. Liu, P. Kong, S. Lou, Y. Su, T. Yang, H. Li, Y. Liu, C. Zhang, L. Gao, L. Zhu, Q. Wen, P. Wang, X. Chen, J. Zhong, and X. Zhang*, Phase II Multicenter, Randomized, Double-Blind Controlled Study of Efficacy and Safety of Umbilical Cord-Derived Mesenchymal Stromal Cells in the Prophylaxis of Chronic Graft-Versus-Host Disease After HLA-Haploidentical Stem-Cell Transplantation. J Clin Oncol, 2016. 34(24): p. 2843-50. DOI: 10.1200/JCO.2015.65.3642
  29. H. Zhu#, Y. Tan#, Q. Gu, W. Han, Z. Li, J. S. Meyer*, and B. Hu*, Regulations in the United States for cell transplantation clinical trials in neurological diseases. Translational Neuroscience and Clinics, 2015. 1(2): p. 114-124. DOI: 10.18679/cn11-6030/r.2015.015
  30. L. Wang#, J. Cao#, Y. Wang#, T. Lan#, L. Liu, W. Wang, N. Jin, J. Gong, C. Zhang, F. Teng, G. Yan, C. Li, J. Li, H. Wan, B. Hu, W. Li, X. Zhao, Z. Qi*, T. Zhao*, and Q. Zhou*, Immunogenicity and functional evaluation of iPSC-derived organs for transplantation. Cell Discov, 2015. 1: p. 15015. DOI: 10.1038/celldisc.2015.15
  31. H. Wan#, C. Feng#, F. Teng#, S. Yang#, B. Hu, Y. Niu, A.P. Xiang, W. Fang, W. Ji, W. Li*, X. Zhao*, and Q. Zhou*, One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system. Cell Res, 2015. 25(2): p. 258-61. DOI: 10.1038/cr.2014.158
  32. W. Shi#, L.I. Zhu#, Y. Wang, B. Hu, H. Xiao, G. Zhou, and C. Chen*, Estrogen therapy to treat retinopathy in newborn mice. Exp Ther Med, 2015. 10(2): p. 611-617. DOI: 10.3892/etm.2015.2554
  33. H. Chen*, K. Qian, W. Chen, B. Hu, L.W.t. Blackbourn, Z. Du, L. Ma, H. Liu, K.M. Knobel, M. Ayala, and S.C. Zhang*, Human-derived neural progenitors functionally replace astrocytes in adult mice. J Clin Invest, 2015. 125(3): p. 1033-42. DOI: 10.1172/JCI69097
  34. S. Wang, W. Li, S. Wang, and B. Hu*, Rapid and efficient assembly of transcription activator-like effector genes by USER cloning. J Genet Genomics, 2014. 41(6): p. 339-47. DOI: 10.1016/j.jgg.2014.05.002
  35. L. Cong, H. Xiao, B. Hu*, and G. Zhou*, Drastic alleviation of neovascularization in oxygen induced retinopathy of mice following intravitreal bone marrow stromal cell transplantation. Chinese Journal of Neuroanatomy, 2014. 30(3): p. 249-260.
  36. M. Wu, G. Chen, and B. Hu*, Induced pluripotency for translational research. Genomics Proteomics Bioinformatics, 2013. 11(5): p. 288-93. DOI: 10.1016/j.gpb.2013.08.001
  37. L. Ma, B. Hu, Y. Liu, S.C. Vermilyea, H. Liu, L. Gao, Y. Sun, X. Zhang, and S.C. Zhang*, Human embryonic stem cell-derived GABA neurons correct locomotion deficits in quinolinic acid-lesioned mice. Cell Stem Cell, 2012. 10(4): p. 455-64. DOI: 10.1016/j.stem.2012.01.021
  38. Y. Jiang, M.J. Zhang, and B.Y. Hu*, Specification of functional neurons and glia from human pluripotent stem cells. Protein Cell, 2012. 3(11): p. 818-25. DOI: 10.1007/s13238-012-2086-6
  39. J. Hao, D. Campagnolo, R. Liu, W. Piao, S. Shi, B. Hu, R. Xiang, Q. Zhou, T. Vollmer, L. Van Kaer, A. La Cava, and F.D. Shi*, Interleukin-2/interleukin-2 antibody therapy induces target organ natural killer cells that inhibit central nervous system inflammation. Ann Neurol, 2011. 69(4): p. 721-34. DOI: 10.1002/ana.22339
  40. B.-Y. Hu and S.-C. Zhang, Directed Differentiation of Neural-stem cells and Subtype-Specific Neurons from hESCs, in Cellular Programming and Reprogramming: Methods and Protocols, S. Ding, Editor. 2010, Humana Press: Totowa, NJ. p. 123-137.
  41. B.Y. Hu, J.P. Weick, J. Yu, L.X. Ma, X.Q. Zhang, J.A. Thomson, and S.C. Zhang*, Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency. Proc Natl Acad Sci U S A, 2010. 107(9): p. 4335-40. DOI: 10.1073/pnas.0910012107
  42. B.Y. Hu and S.C. Zhang*, Differentiation of spinal motor neurons from pluripotent human stem cells. Nat Protoc, 2009. 4(9): p. 1295-304. DOI: 10.1038/nprot.2009.127
  43. B.Y. Hu, Z.W. Du, and S.C. Zhang*, Differentiation of human oligodendrocytes from pluripotent stem cells. Nat Protoc, 2009. 4(11): p. 1614-22. DOI: 10.1038/nprot.2009.186
  44. B.Y. Hu#, Z.W. Du#, X.J. Li, M. Ayala, and S.C. Zhang*, Human oligodendrocytes from embryonic stem cells: conserved SHH signaling networks and divergent FGF effects. Development, 2009. 136(9): p. 1443-52. DOI: 10.1242/dev.029447
  45. Z.W. Du, B.Y. Hu, M. Ayala, B. Sauer, and S.C. Zhang*, Cre recombination-mediated cassette exchange for building versatile transgenic human embryonic stem cells lines. Stem Cells, 2009. 27(5): p. 1032-41. DOI: 10.1002/stem.38
  46. X.J. Li, B.Y. Hu, S.A. Jones, Y.S. Zhang, T. Lavaute, Z.W. Du, and S.C. Zhang*, Directed differentiation of ventral spinal progenitors and motor neurons from human embryonic stem cells by small molecules. Stem Cells, 2008. 26(4): p. 886-93. DOI: 10.1634/stemcells.2007-0620

Notes:  # These authors contributed equally; * Correspondence.

专利:

  1. Zhang SC, Hu BY, Du ZW. Myelinating Oligodendrocyte Precursor Populations, US patent, 2014: US 8658424 B2.
  2. Zhang SC, Hu BY, Du ZW. Method of Generating Myelinating Oligodendrocytes from Embryonic Stem Cells, US patent, 2012: US 8227247 B2.

写给考生的话:

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